Mayuri Vijay Thete

Keywords assembloids organoids thalamus thalamocortical disease Get full text access Log in, subscribe or purchase for full access. References 1. Sherman, S.M. ∙ Guillery, R.W. The role of the thalamus in the flow of information to the cortex Philos. Trans. R. Soc. Lond. B Biol. Sci. 2002; 357:1695-1708 2. Rikhye, R.V. ∙ Gilra, A. ∙ Halassa, M.M. Thalamic regulation of switching between cortical representations enables cognitive flexibility Nat. Neurosci. 2018; 21:1753-1763 3. Roy, D.S. ∙ Zhang, Y. ∙ Aida, T.

Highlights • Generation of hiPS cell-derived 3D spheroids resembling the hindbrain/spinal cord • Synaptically connected corticofugal projections in fused cortico-spinal assembloids • Stimulation of cortical neurons controls skeletal muscle in three-part assembloid • Cellular and functional changes in cortico-motor assembloids maintained long term Summary Neurons in the cerebral cortex connect through descending pathways to hindbrain and spinal cord to activate muscle and generate movement.