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Impaired brain-gut circuit for gut motility dysfunction in mouse models of Parkinson’s disease
ArticleVolume 45, Issue 9117877Open access Affiliations & Notes 1Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China 2National Institute of Biological Sciences, Beijing, 102206, China 3Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 100084, China 4Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research...
Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain
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To determine whether α-Syn-6H-EGFP could be used to explore the pathological effects of α-Syn inclusions on transcription, we performed scRNA-seq on SNc dopaminergic neurons. Single neurons were collected using the patch-seq approach74 (Figure 5A). Neurons with α-Syn-6H-EGFP inclusions were identified by their filamentous structures and enhanced fluorescence (Figure S5A).
By Li Zhang, Minhui Yu, Guoqing Chen, Siyuan Ge, Mengdi Wang, Xianying Zhang, Miao Zhao, Huating Gu, Meizhu Huang, Aixue Liu, Gengxin Ran, Zeyuan Liu, Tiepeng Liao, Qi Chen, Chenjian Miao, Yao Lu Verified, Yibing Wang, Fengchao Wang, Zhihui Liu, Hongying Zhu, Qian Wu, Zhuan Zhou, Wei Xiong, Xiaoqun Wang, Peng Cao
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Cell Press
Verified
Organic Fertilizer with High Nutrient Levels Affected Peanut-Growing Soil Bacteria More Than Fungi at Low Doses
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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