Methods: participants, interventions and outcomes Multicentre, binational pilot, randomised, controlled, open-label, pragmatic trial. Patients from the three participating tertiary PICUs (Queensland Children’s Hospital (QCH), Brisbane, Australia; Sydney Children’s Hospital, Randwick, New South Wales, Australia and University Children’s Hospital Zurich, Zurich, Switzerland) are being enrolled. The study started recruitment on 24 November 2021 with intended completion date of 31 December 2023.