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Meliawati Poniman on Muck Rack

Meliawati Poniman

As seen in: Nature, Wiley Online Library, BioRxiv, Cell Press
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Articles

Structure-based design of stable recombinant hepatitis C virus E1E2 heterodimers

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By Joan Capella-Pujol, Fabien Cannac, Stan Peters, Maddy L. Newby, Meliawati Poniman, Ian Zon, Wouter Olijhoek, Tim Beaumont, Max Crispin, Andrew Ward, Janke Schinkel, Rogier W. Sanders, Kwinten Sliepen, Fabian Mulder
| Nature Verified
Abstract Hepatitis C virus (HCV) affects 47 million people and causes 239,000 deaths annually, yet no vaccine is on the horizon. Generating a stable native-like mimic of the envelope complex E1E2, the only target for known neutralizing antibodies, is an important aim for HCV vaccine development.
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Broadening sarbecovirus neutralization with bispecific antibodies combining distinct conserved targets on the receptor binding domain

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By Denise Guerra, Laura Radić, Mitch Brinkkemper, Meliawati Poniman
| BioRxiv
Abstract Monoclonal neutralizing antibodies (mAbs) are considered an important prophylactic against SARS-CoV-2 infection in at-risk populations and a strategy to counteract future sarbecovirus-induced disease. However, most mAbs isolated so far neutralize only a few sarbecovirus strains. Therefore, there is a growing interest in bispecific antibodies (bsAbs) which can simultaneously target different spike epitopes and thereby increase neutralizing breadth and prevent viral escape.
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Infectious clone of a contemporary Tembusu virus and replicons expressing reporter genes or heterologous antigens from poultry viruses

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By Meliawati Poniman, Linda van Oosten, Kristel Doets, Sjoerd de Cloe
| Wiley Online Library Verified
1 INTRODUCTION Recombinant viral vectors are very powerful tools for gene delivery into eukaryotic cells. These vectors are often applied as human or veterinary vaccine platforms and used in the gene therapy field. The different strategies developed over the years have mostly focused on plasmid-based expression vectors, or large dsDNA viruses such as adeno-, pox- or herpesviruses.
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