Mengying Xia
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Bispecific Antibody Ivonescimab Added to Chemotherapy in EGFR -Variant Non–Small Cell Lung Cancer : The HARMONi-A Randomized Clinical Trial
Key Points Question Does adding ivonescimab to chemotherapy improve overall survival in patients with epidermal growth factor receptor (EGFR) gene variant non–small cell lung cancer after disease progression with EGFR tyrosine kinase inhibitor (TKI) therapy? Findings In this phase 3, randomized, double-blind trial, ivonescimab plus chemotherapy significantly improved overall survival (median, 16.8 vs 14.1 months) and the 30-month survival rate (29.1% vs 18.4%) compared with chemotherapy alone.
Risk-enhancing factors and social determinants of health in risk assessment for atherosclerotic cardiovascular disease
Loading metrics Open Access Peer-reviewed Research Article Citation: Zhang Y, An J, Xia M, Zhou H, Sun Y, Chung J, et al. (2024) Risk-enhancing factors and social determinants of health in risk assessment for atherosclerotic cardiovascular disease. PLoS ONE 19(10): e0312756.
Cardiovascular Risk Associated With Social Determinants of Health at Individual and Area Levels
Key Points Question Does adding individual- or area-level social determinants of health (SDOH) to the pooled cohort equations (PCEs) or the Predicting Risk of CVD Events (PREVENT) equations improve accuracy of risk estimates for atherosclerotic cardiovascular disease (ASCVD)? Findings In this cohort study of 26 316 participants from 4 large US studies, both individual- and area-level of low education, low income, and unemployment were associated with an increased risk of incident ASCVD events.
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