Menuka Karki

Keywords CLDN6 CDH6 EPCAM Hippo pathway renal medullary carcinoma sacituzumab govitecan SMARCB1 TROP2 Introduction Renal medullary carcinoma (RMC) is a rare but highly aggressive cancer that primarily affects young individuals of African descent who carry the sickle cell trait.1,2,3 The defining molecular feature of all RMC cases is the loss of the SMARCB1 tumor suppressor gene in all cases, as identified through immunohistochemistry (IHC).2,4 SMARCB1 plays a critical role in protecting cells...

Introduction Nepal’s High-Level Reforms Committee has proposed recommendations aimed at enhancing sustainable economic growth through effective management of natural resources. This initiative aligns with Part 4 of the 2015 Constitution, which emphasizes the protection, promotion, and sustainable use of water, forest, land, and minerals.

Keywords sickle cell disease renal medullary carcinoma ferroptosis genomic architecture alteration Hi-C H2S SLC7A11 SMARCB1 immune checkpoint inhibitors CD8+ T cells Introduction Sickle cell disease (SCD), the most prevalent inherited blood disorder,1 arises from the homozygous HbS mutation (GAG>GTG: βGlu6Val), causing hemoglobin abnormalities that make red blood cells (RBCs) assume a sickle or crescent shape.2 Individuals with SCD have RBCs prone to hemolysis, leading to vaso-occlusive...