Merete Røineland Benestad

BDR bronchodilator reversibility BPD bronchopulmonary dysplasia BW birth weight COPD chronic obstructive pulmonary disease CPAP continuous positive airway pressure metAHR direct airway hyperresponsiveness to methacholine DLCO diffusing capacity for carbon monoxide DRS dose–response slope, the ratio of maximum percentage decline in FEV1 to cumulative administered dose methacholine EP extremely preterm, ≤28 weeks gestational age or birthweight (BW) ≤1000 g FEV1 forced expiratory volume at 1 s...

BPD bronchopulmonary dysplasia BW birth weight CHQ-CF87 Child Health Questionnaire Child Form-87 CI confidence intervals CP cerebral palsy EP extremely preterm GA gestational age HRQoL Health-related quality of life SF-36 Short Form Health Survey VP very preterm VLBW very low birth weight Transformative changes occurred in perinatal medicine during the 1980s and 1990s; however, the implications for the later health-related quality of life (HRQoL) in adults born extremely preterm (EP) remain...

Discussion This is the first longitudinal population based study to report lung function trajectories from childhood to the mid-30s for extremely preterm-born cohorts, including also the incipient age-related physiological decline. FEV1 tracked in parallel, but significantly below the trajectories of term-born controls, including a parallel peak and onset of the age-related decline from 25 to 35 years.