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Mevaseret Cohen

As seen in: Cell Reports
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Articles

Decidual-tissue-resident memory T cells protect against nonprimary human cytomegalovirus infection at the maternal-fetal interface

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By Or Alfi, Mevaseret Cohen, Shikma Bar-On
| Cell Reports Verified
Highlights • Primary vs. nonprimary HCMV infections are studied in human decidual organ culture model • Nonprimary infected decidual tissues exhibit significant resistance to HCMV infection • HCMV-specific resident memory CD8+ T cells protect against nonprimary decidual infection • The identified correlates of protection can guide the development of HCMV vaccine Summary Congenital cytomegalovirus (cCMV) is the most common intrauterine infection, leading to infant neurodevelopmental disabilities.
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CLPTM1L is a GPI-anchoring pathway component targeted by HCMV

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By Inbal Kol, Ahmed Rishiq, Mevaseret Cohen, Shira Kahlon
| rupress.org
Subjects: Immunology, Membrane and lipid biology, Virology The effects of viruses on a broad range of cellular activities have recently gained increasing interest. One of the affected pathways is that of glycosylphosphatidylinositol (GPI) anchoring. This includes biosynthesis of the GPI moiety, its attachment to precursor proteins, and remodeling and transport of nascent GPI-anchored proteins to the cell surface.
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