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Shikma Bar-On on Muck Rack

Shikma Bar-On

As seen in: Cell Reports
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Articles

Decidual-tissue-resident memory T cells protect against nonprimary human cytomegalovirus infection at the maternal-fetal interface

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By Or Alfi, Mevaseret Cohen, Shikma Bar-On
| Cell Reports Verified
Highlights • Primary vs. nonprimary HCMV infections are studied in human decidual organ culture model • Nonprimary infected decidual tissues exhibit significant resistance to HCMV infection • HCMV-specific resident memory CD8+ T cells protect against nonprimary decidual infection • The identified correlates of protection can guide the development of HCMV vaccine Summary Congenital cytomegalovirus (cCMV) is the most common intrauterine infection, leading to infant neurodevelopmental disabilities.
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