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Articles by Michael Balzer
Nicotinamide nucleotide transhydrogenase deficiency and genetic susceptibility to high glucose‐mediated peritoneal injury in mice
1 INTRODUCTION Peritoneal dialysis (PD) is an established, cost-effective therapy for end-stage renal disease (Davies, 2013; Perl & Bargman, 2009; Thurlow et al., 2021).
Analysis of individual patient pathway coordination in a cross-species single-cell kidney atlas - Nature Genetics
Abstract The use of single-cell RNA sequencing in clinical and translational research is limited by the challenge of identifying cell-type-specific, targetable molecular changes in individual patients and cross-species differences. Here we created an integrated single-cell kidney atlas including over 1 million cells from 140 samples, defining more than 70 conserved cell states in human and rodent models.
Getting out of the house while staying home: introducing the VLBE
by Michael “Baz” Balzer, The Bezark Company, introduction by Adam Bezark. We live in the Golden Age of “Rs.” VR, AR, MR, XR… The tech world keeps bringing us new and gee-whizzier versions of reality to play with. Ultimately, we’re convinced that augmented reality (AR) offers the strongest potential for the real-world destinations our industry creates. Seamlessly blending virtual content with physical scenery is truly the best of both worlds. But what about the O.G. R… good old virtual reality (VR)?
Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression - Nature Genetics
Abstract Kidneys are intricate three-dimensional structures in the body, yet the spatial and molecular principles of kidney health and disease remain inadequately understood. We generated high-quality datasets for 81 samples, including single-cell, single-nuclear, spot-level (Visium) and single-cell resolution (CosMx) spatial-RNA expression and single-nuclear open chromatin, capturing cells from healthy, diabetic and hypertensive diseased human kidneys.
Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization - Nature Communications
Abstract Adiponectin is a secretory protein, primarily produced in adipocytes. However, low but detectable expression of adiponectin can be observed in cell types beyond adipocytes, particularly in kidney tubular cells, but its local renal role is unknown. We assessed the impact of renal adiponectin by utilizing male inducible kidney tubular cell-specific adiponectin overexpression or knockout mice.
Ingenico and Splitit partner to bring white-label, buy now, pay later to physical checkout with just one touch
Ingenico, a global leader in payments acceptance solutions and Splitit, the only white-label, card-based installment platform using existing consumer credit, today announced a global strategic partnership to bring one-touch, no-interest, buy now, pay later capability to the physical checkout experience using PPaaS, Ingenico’s innovative, cloud-based Payments-Platform-as-a-Service, and Splitit’s Installments-as-a-Service solution.
Ingenico enables the rollout of Alipay+
Ingenico and Ant Group have announced details of their partnership that will allow acquirers and other payment service providers to implement Alipay+ seamlessly across their merchant networks using Ingenico’s PPaaS cloud-based solution. PPaaS, leverages the power of the payments ecosystem by combining payments with added-value services for the new world of commerce.
Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis - Nature Immunology
Abstract Inflammation is an important component of fibrosis but immune processes that orchestrate kidney fibrosis are not well understood. Here we apply single-cell sequencing to a mouse model of kidney fibrosis. We identify a subset of kidney tubule cells with a profibrotic-inflammatory phenotype characterized by the expression of cytokines and chemokines associated with immune cell recruitment.
How to Get Started with Single Cell RNA Sequencing Data Analysis
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Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets
Abstract Determining the epigenetic program that generates unique cell types in the kidney is critical for understanding cell-type heterogeneity during tissue homeostasis and injury response. Here, we profile open chromatin and gene expression in developing and adult mouse kidneys at single cell resolution. We show critical reliance of gene expression on distal regulatory elements (enhancers).
How to Get Started with Single Cell RNA Sequencing Data Analysis
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Help Bring a VR Miracle to Sick... by Michael Balzer
Help Bring a VR Miracle to Sick Children this XMAS
Thank God for Girls Lyrics
About “Thank God for Girls” alright kids, let’s play with some gender stereotypes.
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