Sonja Schmidt

1 INTRODUCTION Peritoneal dialysis (PD) is an established, cost-effective therapy for end-stage renal disease (Davies, 2013; Perl & Bargman, 2009; Thurlow et al., 2021).

4. Discussion The aim of this experimental study was to establish an animal model of posttraumatic lymphedema that allows for deeper insights into its pathophysiology and the development of novel therapeutic and prophylactic strategies. In addition, the model was designed to investigate bone regeneration and its interaction with manifest lymphedema.

1 Introduction Ischemia–reperfusion (IR) injury remains a major challenge in free flap surgery, contributing to cellular damage, impaired tissue viability, and potential flap failure [1, 2]. The transient ischemia required for flap harvest and transfer leads to a cascade of molecular and physiological disturbances upon reperfusion [3, 4]. While IR injury has been widely recognised in various organ systems, its precise effects on human free flaps remain incompletely characterised [5-7].