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Michael-Bogdan Margineanu

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Articles

Nociceptive innervation limits tertiary lymphoid structures to promote lung cancer

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By Ya-Hsuan Ho, Giacomo Bregni, Marco Stazi, Paola Peinado, Pei-Hsing Chen, Claudio Ballabio, Victoire Boulat, Shree Vadera, Yilin Guan, Zhikai Liu, Alicia Alonso de la Vega, Li Wang, Chao-Chi Ho, Henrique Veiga-Fernandes, Julian Downward, Min-Shu Hsieh, Maksym V. Kopanitsa, George Kassiotis, Christoforos Tsantoulas, Michael S. Schappe, Dinis Pedro Calado, Isaac M. Chiu, Charles Swanton, Jin-Shing Chen, Leanne Li, Michael-Bogdan Margineanu
| Cell Press Verified
Results We first performed a stage-wise characterization of the innervation landscape in a GEMM of LUAD (Ad5-Spc-Cre, KrasLSL-G12D/+, Trp53fl/fl; Rosa26LSL-tdTomato [KP] model), which recapitulates the LUAD tumorigenesis process observed in patients.26 Staining for the pan-neuronal marker β3-tubulin revealed that pulmonary innervation in the normal lung is mainly concentrated in the large airways (Figures 1A and S1A).
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