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Michael J. Higley on Muck Rack

Michael J. Higley

As seen in: Color Research & Application, Nature, BioRxiv, Cell Press, JNeurosci
Professor, Yale Neuroscience|BME|Psychiatry, Cellular electrophysiologist and imager of cortical circuits, Dada of two boys.
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Articles

SST interneurons facilitate dendritic calcium signaling via tonic activation of α5-GABA receptors

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By Chiayu Q. Chiu, Thomas M. Morse, Karima AitOuares, Lauren C. Panzera, Francesca Nani, Frederic Knoflach, Maria-Clemencia Hernandez, Monika P. Jadi, Michael J. Higley
| Cell Press Verified
Keywords dendrite calcium imaging Introduction Neuronal activity in the mammalian brain is strongly shaped by GABAergic signaling, which is mediated by the release of GABA from local interneurons and the subsequent binding to both ionotropic type-A receptors (GABAARs) and metabotropic type-B receptors.1,2 Broadly, the function of GABAergic transmission, and thus GABAergic interneurons, is thought to be inhibitory, providing a brake on neuronal activity.1,3,4 For example, somatic GABAergic...
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Downregulation of integrin α3 in ADHD mirrored in mutant mouse model by dopamine-dependent hippocampal AMPAR expression - Molecular Psychiatry

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By Jingxiang Zhu, Shitong Xiang, Tianye Jia, He Wang, Jianfeng Feng, Trevor Robbins, Yingwei Wang, Michael J. Higley, Anthony J Koleske
| Nature Verified
Abstract Integrin α3 is critical for proper neuron-glia cell adhesion and dendrite development, implicated in various neurodevelopmental disorders. In this study, mice deficient in integrin α3 (NEX-Itga3-/- mice) exhibit behavioral anomalies that mirror Attention Deficit Hyperactivity Disorder (ADHD), including increased mobility, impulsive disinhibition and impaired working memory.
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Delayed integration of somatostatin interneurons into visual circuits - Nature Communications

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By Alex Wang Verified, Victoria Fan, Michael J. Higley
| Nature Verified
Abstract In primary visual cortex (V1), neuronal receptive fields are generally thought to be fully established prior to eye-opening, with subsequent experience-dependent refinement controlled by GABAergic inhibition and regulated by homeostatic mechanisms. However, GABAergic interneurons (INs) are diverse and relatively little is known about the early postnatal roles of dendrite-targeting interneurons.
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