Michele Bombardieri
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As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Articles
The SjD Map: an interactive pathway tour into Sjögren’s disease signalling mechanisms
Abstract Sjögren’s disease (SjD) remains a major unmet medical challenge, characterised by biological complexity, patient heterogeneity, and the absence of curative treatments. To advance mechanistic understanding and support therapeutic discovery, we developed a comprehensive Molecular Interaction Map (MIM).
Lactate signalling leads to aggregation of immune-inflammatory hotspots and SLC5A12 blockade promotes their resolution - Nature Metabolism
Abstract Ectopic lymphoid structures (ELS) are aggregates of lymphoid cells that often form within inflamed tissues in patients with autoimmune diseases, cancer, infectious diseases and cardiovascular conditions. These structures drive B cell maturation into memory B cells and plasma cells through B cell and T cell co-stimulation, and their role in pathogenesis is increasingly recognized.
Precision medicine in Sjögren's disease
1. Seror R Nocturne G Mariette X Current and future therapies for primary Sjögren syndrome. Nat Rev Rheumatol. 2021; 17: 475-486 2. Ramos-Casals M Brito-Zerón P Bombardieri S et al. EULAR recommendations for the management of Sjögren's syndrome with topical and systemic therapies. Ann Rheum Dis. 2020; 79: 3-18 3. Emerging drugs for primary Sjögren's syndrome. Expert Opin Emerg Drugs. 2019; 24: 121-132 4. Primary Sjögren's syndrome. N Engl J Med. 2018; 378: 931-939 5. Yates LR Seoane J Tourneau CL et al.
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