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Ming-yu Lai on Muck Rack

Ming-yu Lai

As seen in: Nature, Frontiers
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Articles

Vitamin B5 supports anti-PD1 response in HER2-positive gastric cancer and enhances interaction between naïve B cells and T cells

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By Chaoye Wang, Jing Yang, Ming-yu Lai, Jia-Chen Lu, Zhi-Ying Wu, Hai-Yan Zhang, Fang Wang, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Feng-Hua Wang, Wen-Long Guan, Ying Jin, Rui-hua Xu, QI Zhao, Miao-Zhen Qiu, Li-Qiong Yang
| Nature Verified
Abstract The cellular mechanisms underlying HER2-positive gastric cancer (HER2+ GC) responses to immunochemotherapy remain underexplored. Here, we perform longitudinal single-cell RNA-sequencing with paired TCR/BCR profiling on HER2+ and HER2-negative gastric cancer (HER2− GC) pre- and post-treatment to find dynamic immune remodeling during. Pre-treatment HER2+ GC displays an immunogenic microenvironment enriched with tumor-reactive T and B cells compared to HER2− GC.
Open in Who Shared Issue with article?

Evaluating objective nutritional biomarkers for the prediction of sarcopenia in Crohn’s disease: development and internal validation of a clinical nomogram

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By Wen-Tao Deng, Jin-Cheng Li, Xiao-Ling Luo, Guang Xiong, Hai-yuan Zhong, Jing-shuai Huang, Chun-mei Liang, Ming-yu Lai
| Frontiers
Abstract Background: Sarcopenia is prevalent in Crohn’s disease (CD) and correlates with adverse clinical outcomes; however, routine computed tomography (CT) screening is limited in daily practice. This study aimed to comparatively analyze three objective nutritional indices—the Geriatric Nutritional Risk Index (GNRI), Advanced Lung Cancer Inflammation Index (ALI), and Prognostic Nutritional Index (PNI)—and to develop a predictive nomogram for sarcopenia in CD.
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