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Articles by Mingming Xu
Genome mining of the tumor microbiome reveals biosynthetic diversity and potential pathology-modulating metabolites
Abstract Human tumor-associated microbes – the tumor microbiome – have demonstrated an increasingly important role in human health due to their relevance to cancer progression and treatment response. While the metabolism at the host-microbiota interface, such as in the human gut, has been extensively investigated in recent years, the specialized metabolites from the tumor microbiome remain uncharted territory.
Eradication of MRSA biofilm-associated implant infections by low-immunogenic sustained-release lysostaphin fused to thermosensitive polypeptides
Abstract Staphylococcal bacteria, particularly methicillin-resistant Staphylococcus aureus (MRSA), are responsible for intractable infections—especially those associated with implants—through biofilm formation, presenting a worldwide menace. Antibacterial enzymes like lysostaphin (Lst) are promising for combating staphylococcal infections but limited by poor stability, high immunogenicity, and suboptimal pharmacokinetics, which hamper their clinical translation as antibiotic alternatives.
Regulating Host–Guest Interactions in a Mixed-Ligand Metal–Organic Framework for Short-Chain PFAS Detection Click to copy article link Article link copied!
Cite Jump to ExpandCollapse ArticleJune 24, 2026 Regulating Host–Guest Interactions in a Mixed-Ligand Metal–Organic Framework for Short-Chain PFAS Detection Click to copy article linkArticle link copied! Wenhao Huang Wenhao Huang Frontiers Science Center for New Organic Matter, State Key Laboratory of Advanced Chemical Power Sources and Department of Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China Mingming Xu Mingming Xu Frontiers Science Center for New Organic...
Trajectories and timing of accelerated decline in specific memory domains preceding Alzheimer’s disease
Abstract Introduction: Memory impairment is a hallmark feature of Alzheimer’s disease (AD) and may emerge years before clinical diagnosis. However, the temporal sequence and acceleration patterns of decline across specific memory domains during the preclinical stage remain incompletely understood.
Unicentric Pulmonary Castleman Disease Mimicking Lung Cancer: A Case Report
1 Introduction Castleman disease (CD) is a rare lymphoproliferative disorder first described by Castleman in 1954 [1]. It is classified into unicentric CD (UCD) and multicentric CD (MCD) based on the extent of involvement [2]. UCD typically presents as localised lymphadenopathy, most commonly in the mediastinum, and surgical resection is curative [3]. Pulmonary involvement without mediastinal lymphadenopathy is extremely rare [4].
Discovery of seco-(9β-H)-Pimarane Diterpenoids from Icacina oliviformis with Synergistic Anti-Colorectal Cancer Activity
Cite Jump to ExpandCollapse LetterMarch 5, 2026 Discovery of seco-(9β-H)-Pimarane Diterpenoids from Icacina oliviformis with Synergistic Anti-Colorectal Cancer Activity Click to copy article linkArticle link copied! Mingming Xu Mingming Xu Jiangsu Provincial Key Laboratory of Functional Substances in Traditional Chinese Medicine Formulae and Innovative Drug Discovery, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative...
Chiral Au@Ag Nanoparticles Regulate Macrophage Reprogramming for Enhanced Anti‐Tumor Efficacy
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description adfm74228-sup-0001-SuppMat.docx9.2 MB Supporting File: adfm74228-sup-0001-SuppMat.docx. References 1, , , et al., “Chirality Bias Tissue Homeostasis by Manipulating Immunological Response,” Advanced Materials 34 (2022): 2105136.
Disability-Related Loss in Lifespan and Specific Social Determinants of Health Among Middle-Aged and Older Adults with Disabilities: Evidence from China’s Aging Population
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A Spontaneous Nonhuman Primate Model of Inherited Retinal Degeneration
ResearchGeneticsOphthalmology Open Access | 10.1172/jci.insight.190807 JCI Insight. https://doi.org/10.1172/jci.insight.190807. Copyright © 2025, Yi et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Inherited retinal degenerations (IRDs) are important causes of progressive, irreversible blindness.
A Bacterial Sulfotransferase Catalyzes an Unusual Di‐Sulfation in Natural Products Biosynthesis
1 Introduction Sulfur is a ubiquitous element in nature that is present in many essential biomolecules, as well as in many natural products.
Pigmented Skin Disorders in High‐Altitude: Cross‐Sectional Epidemiological Analysis in the General Population of Lhasa, China
1 Introduction The global prevalence of pigmented skin disorders varies significantly. Studies have demonstrated that the prevalence of melasma ranges from 5% to 46% [1-3] depending on the population examined. A population-based study involving 1400 residents revealed a 10% prevalence of plateau facial telangiectasia [4]. Meanwhile, the worldwide prevalence of vitiligo is estimated to range from 0.4% to 2% [5], with a reported prevalence of 0.56% in China [6].
Discovery of A Chimeric Polyketide Family as Cancer Immunogenic Chemotherapeutic Leads
Abstract Discovery of cancer immunogenic chemotherapeutics represents an emerging, highly promising direction for cancer treatment that uses a chemical drug to achieve the efficacy of both chemotherapy and immunotherapy. Herein we report a high-throughput screening platform and the subsequent discovery of a new class of cancer immunogenic chemotherapeutic leads.
Two amino-functionalized metal-organic frameworks with different topologies for C2H2/C2H4 separation
Two amino-functionalized metal-organic frameworks with different topologies for C2H2/C2H4 separation The rational design of metal-organic framework adsorbents is crucial for target gas separation. Herein, we report two three-dimensional MOFs with different topologies by regulating metal ions with amino-functionalized V-type ligands.
An Improved Non-Monotonic Adaptive Trust Region Algorithm for Unconstrained Optimization
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Association of Preoperative High C-Reactive Protein to Albumin Ratio w
Back to Journals » Journal of Inflammation Research » Volume 17 Authors Fang J, Liang H, Lu S, Liao H, Xu M, Chen Y, Li Y, Dong L, Guo Y, Jiang Z, Wei L Received 22 August 2024 Accepted for publication 10 November 2024 Published 21 November 2024 Volume 2024:17 Pages 9255—9268 DOI https://doi.org/10.2147/JIR.S492568 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Adam D Bachstetter Jiamin Fang,1 Hao Liang,2 Shilong...
Asymmetric Charge Distribution in One‐dimensional Metal‐Organic Assemblies to Promote Photocatalytic Hydrogen Evolution
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
The association between different levels of depression and overactive bladder: A cross‐sectional study of the 2005-2018 National Health and Nutrition Examination Survey - Li - 2024 - Neurourology and Urodynamics - Wiley Online Library
Background There is growing evidence of a possible correlation between depression and overactive bladder (OAB). However, few studies have classified depression according to its severity. Whether there is an association between different levels of depression and OAB symptoms remains unclear. Methods Participants with complete information about depression, OAB, and covariates in the National Health and Nutrition Examination Survey (NHANES) 2005–2018 were included in this study.
Multi-dimensional Ergonomic Evaluation Method for Cockpit Light Environment
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 10 May 2024 / Approved: 13 May 2024 / Online: 13 May 2024 (12:27:22 CEST) Zheng, G.; Xu, M.; Xiao, F.; Zhan, C.; Jiang, X. Multi-dimensional Ergonomic Evaluation Method for Cockpit Light Environment. Preprints 2024, 2024050847. https://doi.org/10.20944/preprints202405.0847.v1 Zheng, G.; Xu, M.; Xiao, F.; Zhan, C.; Jiang, X. Multi-dimensional Ergonomic Evaluation Method for Cockpit Light Environment.
A Chlorophyll-a Concentration Inversion Model Based on Backpropagation Neural Network Optimized by an Improved Metaheuristic Algorithm
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Research on Wireless Power Transfer Method for Intelligent Sensing Device of Non-Directly Buried Distribution Cables
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Moving-Target Detection for FDA-MIMO Radar in Partially Homogeneous Environments
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Fault Diagnosis of Oil-Immersed Transformers Based on the Improved Neighborhood Rough Set and Deep Belief Network
1. Introduction Oil-immersed transformers are essential components of power systems and play a critical role in the transmission and distribution of electrical energy [1,2]. However, prolonged operation and high-load conditions can lead to a deterioration in equipment performance, and even severe damage, posing a threat to the stability and reliability of power systems [3,4].
Optimization Scheduling of Virtual Power Plants Considering Source-Load Coordinated Operation and Wind-Solar Uncertainty
1. Introduction With the escalating energy crisis and environmental pollution concerns, the issue of fossil fuel development and utilization has garnered significant attention on the international stage, demanding urgent energy conservation and emissions reduction measures [1,2]. The rapid development of renewable energy generation technologies, represented by wind and solar power, offers new possibilities for addressing these challenges [3].
Correlation between visceral adiposity index and erectile dysfunction in American adult males: a cross-sectional study based on NHANES
Introduction Erectile dysfunction (ED) is the inability to attain and sustain an erection that is sufficiently satisfactory (1, 2). It is an extremely prevalent male disease that usually affects males over the age of 40 (1). It is estimated that about 322 million males will suffer from it by 2025 (3). The mechanism of ED is complex, involving the psychological, neurological, hormonal, and vascular systems.
The association between several serum micronutrients and benign prostatic hyperplasia: Results from NHANES 2003−2006
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. Supporting Information Filename Description pros24641-sup-0001-Supplementary_Materials_1.docx28.5 KB Supporting information. REFERENCES 1, , . Benign prostatic hyperplasia—what do we know? BJU Int. 2021; 127: 389-399. doi:10.1111/bju.15229 2. The epidemiology of benign prostatic hyperplasia associated with lower urinary tract symptoms. Urol Clin North Am. 2016; 43: 289-297. doi:10.1016/j.ucl.2016.04.001 3, .
Novel Molecular Insights into the Effects of Ethoxy Group Number on Emulsification and Viscosity Reduction of Anionic-Nonionic Surfactants
Download Hi-Res ImageDownload to MS-PowerPointCite This:Energy Fuels 2023, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Fe‐based metal‐organic frameworks: from various synthesis, diverse structures to multifunctional applications
Comprehensive Summary Iron-based metal-organic frameworks (Fe-MOFs) have attracted extensive interest from researchers due to their tunability, favorable properties, and chemical versatility. Compared with conventional porous materials, Fe-MOFs exhibit better performance in a wide variety of applications.
Target-specific isolation of light-switchable metal-organic cage within metal-organic framework for tunable CO2 adsorption
Target-specific isolation of light-switchable metal-organic cage within metal-organic framework for tunable CO2 adsorption Yao Jiang, Mingming Xu, Kang Wang, Tao Yang, Shaojun Jia, Xiao-Qin Liu, Peng Cui and Lin-Bing Sun Abstract Light-switchable metal-organic cages (LMOCs), which are intriguing supramolecules with tunable functionality and diverse structural features, have been recognized as the promising candidates for trapping gas molecules.
Automatic Coastline Extraction Based on the Improved Instantaneous Waterline Extraction Method and Correction Criteria Using SAR Imagery
Abstract : Coastlines with different morphologies form boundaries between the land and ocean, and play a vital role in tourism, integrated coastal zone management, and marine engineering. Therefore, determining how to extract the coastline from satellite images quickly, accurately, and intelligently without manual intervention has become a hot topic. However, the instantaneous waterline extracted directly from the image must be corrected to the coastline using the tide survey station data.
IJERPH | Free Full-Text | Socioeconomic Disparities in Individual-Level Quality-Adjusted Life Years throughout Remaining Lifetimes: A National Representative Longitudinal Survey in China
Abstract : Socioeconomic disparities in health within and across low- and middle-income countries pose a significant global public health concern. While prior research has demonstrated the importance of socioeconomic status on health outcomes, few studies have employed comprehensive measures of individual-level health such as quality-adjusted life years (QALYs) in exploring the quantitative relationship.
Recent development in hydrophilic interaction liquid chromatography stationary materials for glycopeptide analysis
Recent development in hydrophilic interaction liquid chromatography stationary materials for glycopeptide analysis Zhaoliang Liu, Mingming Xu, Wenqi Zhang, Xinyu Miao, Perry G. Wang, Shuwei Li and Shuang Yang Abstract Protein glycosylation is one of the most important post-translational modifications, and aberrant glycosylation is associated with the occurrence and development of diseases.
Simplified Edinburgh CT Criteria for Identification of Lobar Intracerebral Hemorrhage Associated With Cerebral Amyloid Angiopathy
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Charge Engineering Reveals the Roles of Ionizable Side Chains in Electrospray Ionization Mass Spectrometry
Characterizing the interactions, stabilities, and conformations of proteins is of central importance in biochemical and pharmaceutical sciences. Native mass spectrometry (MS) informs about the molecular weight of protein complexes to reveal oligomeric states and ligand binding. (1−3) Combined with ion mobility (IM), it can be used to determine collision cross sections (CCS) and identify conformational changes.
Isolation and characterization of alternatively spliced variants of the mouse sigma1 receptor gene, Sigmar1
The sigma receptor acts as a chaperone at the endoplasmic reticulum, associates with multiple proteins in various cellular systems, and involves in a number of diseases, such as addiction, pain, cancer and psychiatric disorders. The sigma receptor is encoded by the single copy SIGMAR1 gene. The current study identifies five alternatively spliced variants of the mouse sigma receptor gene using a polymerase chain reaction cloning approach.
Structural mechanism of flavonoids in inhibiting serine proteases
Quercetin is a member of flavonoids and was previously demonstrated to inhibit trypsin-like serine proteases at micromolar potencies. Different molecular models were proposed to explain such inhibition. However, controversies remain on molecular details of inhibition. Here, we report the X-ray crystal structure of quercetin in complex with urokinase-type plasminogen activator (uPA), an archetypical serine protease.
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