Mingshun Han on Muck Rack

Mingshun Han

As seen in: Nature, Cell Press
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Articles

Targeting PID1 generates oxysterols to switch macrophage cell fates for improved antitumor immunity

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By Yuxiao Zheng, Qi Wang, Chen Dong, Qiong Wang, Mingshun Han, Haiqing Zhao, Shuang Wang, Longlong Chen, Xiaoli Zhang, Dan Yang, Jun Xiao, Zhihuan Chew, Zhenfei Xie, Xin Zheng, Weiyun Li, Lijian Hui, Xiaowu Huang, Jinsong Li, Huiru Tang, Bin Wei, HONGYAN WANG, Jinyong Fan, Dezhen Tu, Lingming Zheng
| Nature Verified
Abstract Disordered cholesterol–oxysterol profiles are observed in the tumor microenvironment, yet their roles in tumor-associated macrophages (TAMs) remain underexplored. This study reveals that TAMs across human pan-cancers exhibit elevated phosphotyrosine interaction domain-containing protein 1 (PID1) expression and prominent immunosuppressive gene signatures.
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