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Abstract The liver plays an important role in cardiovascular disease by amplifying systemic inflammation, while the underlying mechanisms remain to be defined. Soluble epoxide hydrolase (sEH) is a pro-inflammatory enzyme, and pharmacological inhibition of sEH was shown to protect against various inflammatory diseases. In this study, we have identified a novel role of the liver, through expression of sEH, in the pathogenesis of abdominal aortic aneurysm (AAA).
There is intense focus now on how to reach a peace agreement in Afghanistan, but little on how to sustain peace, particularly in an area that bores so many policymakers and pundits: economics. Yet peace with inadequate economic support risks adding demobilized soldiers and Taliban to the large numbers of unemployed Afghans.
After months of deliberation, President Trump has taken a step in the right direction by renewing America’s commitment to Afghanistan. In his speech Monday night, Mr. Trump wisely refrained from specifying troop numbers and deadlines. Crucially, he also demanded Pakistan cease its support of Afghanistan’s insurgents, calling out Islamabad’s meddling more publicly than previous administrations were willing to do.
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