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Peter A Calabresi on Muck Rack

Peter A Calabresi

As seen in: Nature, Wiley Online Library, Memory Studies, ScienceDirect, Frontiers, PNAS, SAGE Publishing, Medscape, The New England Journal of Medicine, BioRxiv and
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Articles

Towards a biologically informed description of multiple sclerosis disease course — a roadmap for transition

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By Fred Lublin, Lindsay Rechtman, James Quinn, Maria amato, Bruce F Bebo, Peter A Calabresi, Julie Fiol, Marcia Finlayson, Annie Hawton, Tanja Kuhlmann, Ruth Ann Marrie, Marcello Moccia, Xavier Montalban, Michael Panzara, Kathy Smith, Maria Pia Sormani, Jon Strum, Barbara G. Vickrey, Timothy Coetzee
| Nature Verified
Abstract Contemporary management of multiple sclerosis is based on the clinical course descriptors of relapsing–remitting, secondary progressive and primary progressive. However, recognition is growing in the field that these clinical course descriptors do not capture the full disease spectrum of multiple sclerosis or reflect the underlying biological mechanisms of disease, and that biologically informed course descriptors are needed.
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Challenges and future directions for multiple sclerosis after the 2024 McDonald diagnostic criteria

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By Jiwon Oh, Frederik Barkhof, Amit Bar-Or, Timothy Coetzee, Massimo Filippi, Cristina Granziera, Yael Hacohen, Bernhard Hemmer, Orhun Kantarci, Ho Jin Kim, Christine Lebrun-Frenay, Xavier Montalban, Ellen M Mowry, Daniel Ontaneda, Alexandre Prat, Daniel S. Reich, Alex Rovira, Pascal Sati, Aksel Siva, Andrew Solomon, Maria Pia Sormani, Bruno Stankoff, Mar Tintoré, Anthony L. Traboulsee, Anneke van der Walt, Heinz Wiendl, Peter A Calabresi, Olga Ciccarrelli
| Nature Verified
The 2024 revision of the McDonald diagnostic criteria is an important step toward earlier and more inclusive diagnosis of multiple sclerosis. Realizing its full potential will require continued refinement of biomarkers, disease stratification and clinical trial approaches.
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Oligodendrocyte Piezo2 is a regulator of age-dependent myelin integrity and dysregulated in multiple sclerosis

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By Celine Geywitz, Christina Mayer, Celia Lerma-Martin, Matthew Smith, Heidrun Potschka, Peter A Calabresi, Klaus-Armin Nave, Manuel A. Friese, Wiebke Möbius, Lucas Schirmer, Julia Dyckow-Schubart, Amelie M. Rabitsch, Natalie Ludwig
| Nature Verified
Abstract Studies on the mechanosensitive ion channel Piezo2 largely focus on its role in the peripheral nervous system, particularly in touch and pain sensation. Here, we investigate Piezo2 function in the anterior visual pathway of the central nervous system with a focus on oligodendrocyte (OL) biology and myelin integrity. Using single-nucleus RNA sequencing, we identify Piezo2 expression in late differentiated OLs of the murine optic nerve, with minor expression in retinal ganglion cells.
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