Monjoy Saha

Abstract In spite of the growing interest in the microbiome in human cancer, there are currently only small-scale lung cancer microbiome studies conducted directly on tissue. As part of the Sherlock-Lung study, we studied the microbiomes of 940 lung cancers (4090 samples) in never smokers (LCINS) directly from lung tissue using three data types: 16S rRNA gene sequencing (16S), whole-genome sequencing (WGS) with paired blood, and RNA-seq.

Abstract Understanding lung cancer evolution can identify tools for intercepting its growth1,2. Here, in a landscape analysis of 1,024 lung adenocarcinomas (LUADs) with deep whole-genome sequencing integrated with multiomic data, we identified 542 LUADs with a diverse clonal architecture. In this group, we observed divergent evolutionary trajectories based on tobacco smoking exposure, ancestry and sex.

Abstract Radiotherapy increases contralateral breast cancer risk, while hormone therapy reduces it; their combined effects are unclear. Data from two US retrospective cohort studies of 5-year breast cancer survivors (stage I-III, ages 20–84), Kaiser Permanente (KP, 1990–2012) and SEER (1990–2013), were analysed. Contralateral breast radiation doses were estimated for the KP cohort.