Tongwu Zhang

Correction to: Nature https://doi.org/10.1038/s41586-025-09825-y Published online 10 December 2025 It has been drawn to our attention that some statements in the initially published version of this article could be interpreted as supporting a direct mechanistic role for ZNF695 in L1 regulation. As there was no experimental evidence for such a role, the article has been corrected.

Keywords endogenous retroviral RNA ERV RNA melanoma nuclear exosome targeting complex NEXT complex nuclear RNA surveillance zebrafish Research topic(s) CP: cancer CP: molecular biology Introduction As healthy cells require appropriate levels of high-quality RNA, dysregulation of RNA homeostasis contributes to diverse human diseases, including cancer. RNA homeostasis requires balanced production and degradation.

Abstract We previously identified diverse genetic evolutionary patterns in whole-genome sequencing of paired normal tissue adjacent to tumor (NAT) and tumor tissues from Hong Kong breast cancer (HKBC) patients. Here, we investigated whether DNA methylation (DNAm) contributes to NAT heterogeneity and shapes the tumor microenvironment (TME). Genome-wide DNAm profiling was performed on paired NAT and tumor tissues from 188 HKBC patients using the Infinium 850 K array.