Myrto Andreadou

Keywords regulatory T cells Foxp3 type 1 responses GM-CSF Treg suppressor function IL-2 tissue-invading phagocytes inflammation Research topic(s) CP: Immunology Introduction Autoimmune diseases affect approximately 10% of the world’s population, and their prevalence is increasing.1 These conditions arise when parts of the immune system attack and destroy otherwise normal and healthy tissues.2 Despite thymic negative selection, peripheral autoreactive T cells are found abundantly in healthy...

Abstract Neuroinflammation including interleukin (IL)-12/IL-23-signaling is central to Alzheimer’s disease (AD) pathology. Inhibition of p40, a subunit of IL-12/IL-23, attenuates pathology in AD-like mice; however, its signaling mechanism and expression pattern remained elusive. Here we show that IL-12 receptors are predominantly expressed in neurons and oligodendrocytes in AD-like APPPS1 mice and in patients with AD, whereas IL-23 receptor transcripts are barely detectable.

Abstract Regulatory T (Treg) cells are critical for maintaining peripheral tolerance and preventing autoimmunity. Treg cell depletion or dysfunction rapidly results in fatal multiorgan inflammation linked to unrestrained effector T cell expansion, but the cytokine network underlying immunopathology, and its direct cellular mediators, remain elusive.