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Articles

Adenophages are an atypical macrophage population in exocrine glands sustained by ILC2-derived GM-CSF - Nature Immunology

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By Victor Kreiner, Aline Ignácio, David Bejarano, Mitchell Bijnen, Hannah Van Hove, Colin Sparano, Ricardo Fróis-Martins, Alexandre Gallerand, Laura Oberbichler, Rachel Lindemann, Anja Kipar, Kathy McCoy, Calum C. Bain, Christoph Schneider, Stoyan Ivanov, Sonia Tugues, Melanie Greter, Florent Ginhoux, Andreas Schlitzer, Elaine Emmerson, Donatella DeFeo, Salomé Leibund Gut-Landmann
| Nature Verified
Abstract Granulocyte-macrophage colony-stimulating factor (GM-CSF, Csf2) is a potent proinflammatory cytokine1. At steady state, however, GM-CSF has a distinct homeostatic function, being essential for the differentiation and maintenance of alveolar macrophages2,3,4,5. Whether macrophage development in nonpulmonary tissues is similarly dependent on GM-CSF is unclear. Here we examine developing tissues of GM-CSF fate-mapping and reporter mice6.
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Regulatory T cells suppress GM-CSF-producing T helper cells via IL-2 modulation to restrain immunopathology

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By Sara Costa-Pereira, Margit Lanzinger, Nicolas Nuñez, Juan Villar-Vesga, Myrto Andreadou, Francesco Prisco, Philipp Häne, Sinduya Krishnarajah, Rachel Lindemann, Laura Oberbichler, Frederike Westermann, Virginia Cecconi, Sonia Tugues, Sarah Mundt, Melanie Greter, Donatella De Feo, Burkhard Becher, Elsa Roussel, Mirjam Pinzger
| Cell Reports Verified
Keywords regulatory T cells Foxp3 type 1 responses GM-CSF Treg suppressor function IL-2 tissue-invading phagocytes inflammation Research topic(s) CP: Immunology Introduction Autoimmune diseases affect approximately 10% of the world’s population, and their prevalence is increasing.1 These conditions arise when parts of the immune system attack and destroy otherwise normal and healthy tissues.2 Despite thymic negative selection, peripheral autoreactive T cells are found abundantly in healthy...
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