Skip To Main Content
Myung-Kwan Han on Muck Rack

Myung-Kwan Han

As seen in: The Journal of Biological Chemistry
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Myung-Kwan

Contact Myung-Kwan, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Platelet-activating Factor Mediates Endotoxin Tolerance by Regulating Indoleamine 2,3-Dioxygenase-dependent Expression of the Suppressor of Cytokine Signaling 3

|
By Kyung Tae Noh, In Duk Jung, Myung-Kwan Han
| The Journal of Biological Chemistry Verified
Indoleamine 2,3-dioxygenase (IDO) mediates immune tolerance, and suppressor of cytokine signaling 3 (SOCS3) negatively regulates the JAK/STAT signal transduction pathway. We determined previously that platelet-activating factor (PAF) protects mice against LPS-induced endotoxic shock, but its detailed mechanism of action was unknown. We performed survival experiments in IDO+/+ and IDO?/? mice using an LPS-induced endotoxemia model and rated organ injury (neutrophil infiltration and liver function).
Open in Who Shared Issue with article?

Platelet-activating factor mediates endotoxin tolerance by regulating indoleamine 2,3-dioxygenase-dependent expression of the suppressor of cytokine signaling 3

|
By Kyung Tae Noh, In Duk Jung, Myung-Kwan Han, Yeong-Min Park
| The Journal of Biological Chemistry Verified
Author contributions: KTN designed, performed and analzed the experiments shown in Fig 1,2, 3 and 6, and and wrote the paper. IDJ designed, performed and analzed the experiments shown in Fig 4,5, and 7. GSC provided technical assistance and contributd to the design and preparion of the figures. MKH and YMP conceived and coordinated the study and wrote the paper. All authors reviewed the results and approved the final version of the manuscript.
Open in Who Shared Issue with article?
See all 2 articles