Nagham Alouche

Keywords lymph node fibroblastic reticular cells dendritic cells Notch signaling CD8+ T memory precursor cells T cell zone compartmentalization Ccl19 Ccr7 secondary lymphoid organs homeostasis Introduction Secondary lymphoid organs (SLOs) such as lymph nodes (LNs), Peyer’s patches (PPs), and spleen are strategically positioned to filter local body fluids and function as sites of antigen-specific T and B lymphocyte activation against pathogens and cancer.

Keywords cancer immunity dendritic cells immunotherapy cancer immunity cycle regulatory T cells chemokines Introduction The cancer immunity cycle comprises a series of rate-limiting events that collectively drive antitumor immune responses.1 Conventional dendritic cells (cDCs) are critical to this cycle, as their presence and function in different tissues determine T cell activation and effector responses.

Abstract Bladder cancer (BC) is a prevalent malignancy with poor prognosis in advanced stages. While immune checkpoint blockade has revolutionized immunotherapy, its efficacy remains limited for most advanced BC patients. The detailed characterization of BCs tumor microenvironment (TME) is a prerequisite to understand these mechanisms of resistance and to develop new therapeutic strategies.