Sanjiv A. Luther

Keywords lymph node fibroblastic reticular cells dendritic cells Notch signaling CD8+ T memory precursor cells T cell zone compartmentalization Ccl19 Ccr7 secondary lymphoid organs homeostasis Introduction Secondary lymphoid organs (SLOs) such as lymph nodes (LNs), Peyer’s patches (PPs), and spleen are strategically positioned to filter local body fluids and function as sites of antigen-specific T and B lymphocyte activation against pathogens and cancer.

Keywords cancer immunity dendritic cells immunotherapy cancer immunity cycle regulatory T cells chemokines Introduction The cancer immunity cycle comprises a series of rate-limiting events that collectively drive antitumor immune responses.1 Conventional dendritic cells (cDCs) are critical to this cycle, as their presence and function in different tissues determine T cell activation and effector responses.

1Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA 2Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA 3Department of Immunobiology, University of Lausanne, Epalinges, Switzerland 4Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI, USA 5Immunology Graduate Group, University of Pennsylvania, Philadelphia, PA, USA 6Children’s Hospital of Philadelphia,...