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Articles by Nancy Bird
Letter: Welcome to the inconceivable logic of the Alaska Division of Elections
So, Division of Elections Director Carol Beecher is convinced that retired schoolteacher Dan J. Sullivan is ineligible to run for the U.S. Senate. Yet the director has no problem with a convicted felon who is still in prison being a candidate for the U.S. House? That same felon and his mother, who is a U.S. Senate candidate, list their home addresses in South Dakota.
The reliability of inferred archaic segments
We ran three separate demography simulations in msprime (Figures 1, S2, S3, S4, parameters in Text S1): one from Skov et al., 2018 simulating East Asian history with a unique bottleneck in the target population, one from Gower et al., 2021 simulating West Eurasian demography with a large recent increase in population size, and one with both Neanderthal and Denisovan introgression into a Papuan population, with parameters taken from the stdpopsim catalogue ‘Out-of-Africa with archaic admixture...
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Opinion: Johnson County LOST is a testament to what's possible
The Gazette offers audio versions of articles using Instaread. Some words may be mispronounced. As President and CEO of Greater Iowa City, Inc., I’m proud to support the local-option sales tax (LOST) on the ballot Nov. 4 in Iowa City, Coralville, and North Liberty.
Letter: Gaza
Gaza is approximately the same size as Turnagain Arm. Can you imagine what three weeks of relentless bombing would do to that tiny sliver of land? Add in 2.3 million people, approximately 40,000 of whom are Hamas members, and imagine who dies when the bombs drop. Yes, as the Israeli spokesperson said, “That’s what happens in war,” in response to their vicious bombing of a refugee camp. I vehemently protest my tax dollars being used to support Israel’s inhumane and illegal actions.
African Civilizations That Left a Lasting Global Legacy
By Nancy Bird Pre-colonial African history is alive with tales of civilizations rising and falling and of different cultures intermingling across the continent. We have now shed more light on some of these societies using the science of genetics. In a study published in Science Advances, my co-authors and I used DNA information from people from the present-day continent to shed light on important civilizations that existed before colonialism.
DNA study opens a window into African civilisations that left a lasting legacy Original
Pre-colonial African history is alive with tales of civilizations rising and falling and of different cultures intermingling across the continent. We have now shed more light on some of these societies using the science of genetics. In a study published in Science Advances, my co-authors and I used DNA information from people from the present-day continent to shed light on important civilisations that existed before colonialism. Genetic information from blood samples was extracted by machines.
DNA study opens a window into African civilisations that left a lasting legacy
Pre-colonial African history is alive with tales of civilisations rising and falling and of different cultures intermingling across the continent. We have now shed more light on some of these societies using the science of genetics. In a study published in Science Advances, my co-authors and I used DNA information from people from the present-day continent to shed light on important civilisations that existed before colonialism. Genetic information from blood samples was extracted by machines.
DNA study opens a window into African civilisations that left a lasting legacy Original
Pre-colonial African history is alive with tales of civilisations rising and falling and of different cultures intermingling across the continent. We have now shed more light on some of these societies using the science of genetics. In a study published in Science Advances, my co-authors and I used DNA information from present-day African people to shed light on important civilisations that existed before colonialism. Genetic information from blood samples was extracted by machines.
Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics
DISCUSSION We set out to improve our understanding of the mechanisms underpinning cytomotive behaviors of protein filaments. Our approach was to complete a structural survey of the actin and tubulin superfamilies not only via the assembly of existing datasets but also by generating previously unknown data to fill important gaps.
Sensitive photodetection below silicon bandgap using quinoid-capped organic semiconductors
Abstract High-sensitivity organic photodetectors (OPDs) with strong near-infrared (NIR) photoresponse have attracted enormous attention due to potential applications in emerging technologies. However, few organic semiconductors have been reported with photoelectric response beyond ~1.1 μm, the detection limit of silicon detectors.
Two triplet emitting states in one emitter: Near-infrared dual-phosphorescent Au20 nanocluster
Information Published In Science Advances Volume 9 | Issue 13 March 2023 Copyright Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
Aberrant cell state plasticity mediated by developmental reprogramming precedes colorectal cancer initiation
Abstract Cell state plasticity is carefully regulated in adult epithelia to prevent cancer. The aberrant expansion of the normally restricted capability for cell state plasticity in neoplasia is poorly defined. Using genetically engineered and carcinogen-induced mouse models of intestinal neoplasia, we observed that impaired differentiation is a conserved event preceding cancer development.
A movable unshielded magnetocardiography system
Exercise MCG signal With the wearable OPM, the eMCG signal is further measured to demonstrate the feasibility of detecting MCG signals of freely behaving participants in an unshielded Earth’s field. Similar to the eECG, eMCG records the heart’s response to the stress of exercise. We measure the eMCG signals for three healthy male individuals aged between 22 and 25 years old. During the measurement, the participants wearing our MCG system (see Fig.
ATP-releasing SWELL1 channel in spinal microglia contributes to neuropathic pain
Abstract Following peripheral nerve injury, extracellular adenosine 5′-triphosphate (ATP)–mediated purinergic signaling is crucial for spinal cord microglia activation and neuropathic pain. However, the mechanisms of ATP release remain poorly understood. Here, we show that volume-regulated anion channel (VRAC) is an ATP-releasing channel and is activated by inflammatory mediator sphingosine-1-phosphate (S1P) in microglia.
Active recruitment of anti-PD-1-conjugated platelets through tumor-selective thrombosis for enhanced anticancer immunotherapy
Abstract Immune checkpoint inhibitors (ICIs) can reinvigorate T cells to eradicate tumor cells, showing great potential in combating various types of tumors. We propose a delivery strategy to enhance tumor-selective ICI accumulation, which leverages the responsiveness of platelets and platelet-derivatives to coagulation cascade signals.
A customized MOF-polymer composite for rapid gold extraction from water matrices
Abstract With the fast-growing accumulation of electronic waste and rising demand for rare metals, it is compelling to develop technologies that can promotionally recover targeted metals, like gold, from waste, a process referred to as urban mining. Thus, there is increasing interest in the design of materials to achieve rapid, selective gold capture while maintaining high adsorption capacity, especially in complex aqueous-based matrices.
Accelerated mafic weathering in Southeast Asia linked to late Neogene cooling
Abstract Arc-continent collision in Southeast Asia during the Neogene may have driven global cooling through chemical weathering of freshly exposed ophiolites resulting in atmospheric CO2 removal. Yet, little is known about the cause-and-effect relationships between erosion and the long-term evolution of tectonics and climate in this region.
Regiodivergent catalytic asymmetric dearomative cycloaddition of bicyclic heteroaromatics
Abstract The catalytic dearomative cycloaddition of bicyclic heteroaromatics including benzofurans and indoles provides rapid access to functionalized heterocyclic molecules. Because of the inherent stereoelectronic differences, the furan or pyrrole nucleus is more prone to dearomative cycloaddition than the benzene ring. Here, we realized a geometry-based differentiation approach for achieving C6-C7 and C7-C7a regioselectivity.
Hemagglutinin destabilization in H3N2 vaccine reference viruses skews antigenicity and prevents airborne transmission in ferrets
Information Published In Science Advances Volume 9 | Issue 13 March 2023 Copyright Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
A simple, time- and cost-effective, high-throughput depletion strategy for deep plasma proteomics
Information Published In Science Advances Volume 9 | Issue 13 March 2023 Copyright Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
Mechanism of sphingolipid homeostasis revealed by structural analysis of Arabidopsis SPT-ORM1 complex
Abstract The serine palmitoyltransferase (SPT) complex catalyzes the first and rate-limiting step in sphingolipid biosynthesis in all eukaryotes. ORM/ORMDL proteins are negative regulators of SPT that respond to cellular sphingolipid levels. However, the molecular basis underlying ORM/ORMDL-dependent homeostatic regulation of SPT is not well understood.
The super elongation complex drives transcriptional addiction in MYCN-amplified neuroblastoma
Information Published In Science Advances Volume 9 | Issue 13 March 2023 Copyright Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics
Structural analysis All analyses were carried out using custom scripts written in R, making extensive use of the bio3d (12) and tidyverse (64) packages. Structure datasets were collected programmatically from the PDB (April 2021) by running individual phmmer (65) searches of PDB sequences with a representative from each of the subfamilies investigated. Sequences from the downloaded PDB depositions were extracted and aligned as follows.
Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors
Abstract Vaccines and drugs have helped reduce disease severity and blunt the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, ongoing virus transmission, continuous evolution, and increasing selective pressures have the potential to yield viral variants capable of resisting these interventions. Here, we investigate the susceptibility of natural variants of the main protease [Mpro; 3C-like protease (3CLpro)] of SARS-CoV-2 to protease inhibitors.
Dense sampling of ethnic groups within African countries reveals fine-scale genetic structure and extensive historical admixture
1) Does genetic structure vary with geography, language, and/or ethnic group within each of Cameroon, Republic of the Congo, Ghana, Nigeria, and Sudan, as has been observed within other African countries (1, 7, 8)? 2) The Grassfields of Cameroon, broadly located in the Northwest and West regions (Fig. 1, box A), has a long and complex history of multiple polities of different sizes (35). Does genetic structure correlate with these historical polities?
C4 gene induction during de-etiolation evolved through changes in cis to allow integration with ancestral C3 gene regulatory networks
A cis-regulatory atlas for de-etiolation in G. gynandra The chromatin accessibility assays and in silico analysis above identified regulatory elements that could be important for gene regulation but cannot indicate whether motifs were actually bound by transcription factors. We therefore carried out sequencing at sufficient depth to define DNA sequences protected from DNase I digestion.
Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes
Abstract Glioblastoma (GBM) is the most common and aggressive primary brain cancer. Despite multimodal treatment including surgery, radiotherapy, and chemotherapy, median patient survival has remained at ~15 months for decades. This situation demands an outside-the-box treatment approach. Using magnetic carbon nanotubes (mCNTs) and precision magnetic field control, we report a mechanical approach to treat chemoresistant GBM.
Ultralow-dose binary oncolytic/helper-dependent adenovirus promotes antitumor activity in preclinical and clinical studies
Abstract We show that a binary oncolytic/helper-dependent adenovirus (CAdVEC) that both lyses tumor cells and locally expresses the proinflammatory cytokine IL-12 and PD-L1 blocking antibody has potent antitumor activity in humanized mouse models. On the basis of these preclinical studies, we treated four patients with a single intratumoral injection of an ultralow dose of CAdVEC (NCT03740256), representing a dose of oncolytic adenovirus more than 100-fold lower than used in previous trials.
mRNA translational specialization by RBPMS presets the competence for cardiac commitment in hESCs
RBPMS controls mRNA translation of factors that are essential to initiate cardiac mesoderm commitment To determine how the loss of RBPMS causes translation inhibition in hESCs and prevents cardiac mesoderm commitment, we first applied translation state RNA sequencing (TS-seq) to investigate transcriptome-wide changes in the occupancy of ribosomal complexes upon RBPMS loss in hESCs. To this end, transcripts associated with ribosomal complexes (the 40S, 80S, light, and heavy polysomes) were...
Adaptive tuning of human learning and choice variability to unexpected uncertainty
Abstract Human value–based decisions are notably variable under uncertainty. This variability is known to arise from two distinct sources: variable choices aimed at exploring available options and imprecise learning of option values due to limited cognitive resources. However, whether these two sources of decision variability are tuned to their specific costs and benefits remains unclear.
Caterpillar-inspired soft crawling robot with distributed programmable thermal actuation
Abstract Many inspirations for soft robotics are from the natural world, such as octopuses, snakes, and caterpillars. Here, we report a caterpillar-inspired, energy-efficient crawling robot with multiple crawling modes, enabled by joule heating of a patterned soft heater consisting of silver nanowire networks in a liquid crystal elastomer (LCE)–based thermal bimorph actuator.
Fishing through the cracks: The unregulated nature of global squid fisheries
Abstract While most research has focused on the legality of global industrial fishing, unregulated fishing has largely escaped scrutiny. Here, we evaluate the unregulated nature of global squid fisheries using AIS data and nighttime imagery of the globalized fleet of light-luring squid vessels. We find that this fishery is extensive, fishing 149,000 to 251,000 vessel days annually, and that effort increased 68% over the study period 2017–2020.
Letter to the Editor: Protect your friends and neighbors
Linden O’Toole receives a coronavirus vaccine from medical assistant Jim Cabusora. Being vaccinated made O’Toole “the happiest person in town,” she said. (Feb. 6, 2021) Photo by Zachary Snowdon Smith/The Cordova Times It is very sad that Cordova is experiencing so many new COVID-19 cases. Good time to remind everyone that we are all in this together and it will take all of us working together to get through it. Masks mainly protect your friends; when they, in turn, are masked, we’re all protected.
Letter to the Editor: It's time for Republicans to acknowledge Biden win
Joe Biden speaks with supporters at Sun City MacDonald Ranch in Henderson, Nev. (Feb. 14, 2020) Photo courtesy of Gage Skidmore Dear Editor, While my friend, Mark Irving, does not call himself “political,” (Cordova Times, Nov. 6) I remember making political buttons for his city council campaign decades ago! I congratulate his organizing skills and am glad the truck rally made those who participated feel optimistic.
Letter: Baffling
Watching the enthusiastic Trump supporters in Freedom Plaza on Nov. 14 baffled me. Why would such hard-working, patriotic Americans clap and cheer a man driving by on his way to the golf course? — Nancy Bird Cordova Have something on your mind? Send to letters@adn.com or click here to submit via any web browser. Letters under 200 words have the best chance of being published. Writers should disclose any personal or professional connections with the subjects of their letters.
This giving season, consider supporting the Strengthen Grow Evolve campaign and the future of the arts in Iowa City
In what has proven to be a truly extraordinary year, Iowa City’s “town” and “gown” have both been put under extreme pressure. As members of FilmScene’s Board of Directors and the Strengthen Grow Evolve steering committee, we are asking that you direct your support to our local arts community this giving season. The Englert and FilmScene are flagships of downtown Iowa City and create a cultural hub for citizens and students alike.
'This is resilience': A message from the Iowa City Downtown District after new closures
While the year has been difficult, this week has been exceptionally heart-wrenching for the Downtown District. What began as a community-minded collaborative effort to both stop the spread of COVID-19 and maintain our economic future has devolved quickly, and the second wave of restaurant restrictions and bar closures predictably came to pass on Thursday.
Celebrate National Women’s Month in downtown Iowa City this March
Nancy Bird Published 11:37 a.m. CT March 6, 2020 | Updated 11:39 a.m. CT March 6, 2020 Buy Photo Community members gather while holding up signs readings, "Equal pay for equal work!" and "...and still I rise, I rise, I rise!" during the "Women's March" on Saturday, Jan. 19, 2019, along the pedestrian mall in downtown Iowa City, Iowa.
A glimpse into 2017 for Downtown Iowa City
Having weathered a challenging construction schedule on Washington Street in 2016, it’s nice to have the year in the rearview mirror and some exciting endeavors to look forward to in 2017. First, we’ll be able to enjoy the fresh new streetscape of Washington Street. You will no longer experience walking over unstable vault doors, tripping hazards in cracked sidewalks or confusing back-in parking.
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