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Neil Brockdorff on Muck Rack

Neil Brockdorff

Oxford
As seen in: Nature, BioRxiv, Cell Reports, Cell Press
Research scientist working on X chromosome inactivation, polycomb proteins, DNA methylation and related.
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Articles

Selective interaction of SMCHD1 with chromatin is governed by LRIF1 and SMCHD1 ATPase activity

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By Aleksander T Szczurek, Tatyana B. Nesterova, Guifeng Wei, Mafalda Almeida, Jessica Kelley, Stephan Uphoff, Adam D. Cawte, Neil Brockdorff, Flavia Constantinescu, Victoria Pustygina
| Nature Verified
Abstract The chromosomal protein SMCHD1 is a GHKL ATPase with important roles in epigenetic silencing, including on the inactive X chromosome (Xi). Mutations of SMCHD1 have been linked to facioscapulohumeral muscular dystrophy (FSHD) and Bosma arrhinia microphthalmia syndrome (BAMS). Here, we use live-cell and single-molecule imaging to investigate SMCHD1 interactions with chromatin and its function in epigenetic silencing.
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SETDB1 and HUSH modulate Xist RNA levels during establishment of X chromosome inactivation

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By Mafalda Almeida, Guifeng Wei, Tatyana B. Nesterova, Neil Brockdorff, Adam D. Cawte
| Nature Verified
Abstract The non-coding RNA Xist mediates X chromosome inactivation (XCI) in mammals, functioning in cis to direct heterochromatin formation over a single X chromosome in cells of early female embryos. Prior studies have determined that Xist transcription and turnover are modulated to maintain the correct level of Xist RNA to inactivate a single X chromosome. The underlying molecular mechanisms are poorly understood.
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Hbo1 and Msl complexes preserve differential compaction and H3K27me3 marking of active and inactive X chromosomes during mitosis - Nature Cell Biology

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By Dounia Djeghloul, Holger Kramer, àlex Montoya, Tatyana B. Nesterova, Guifeng Wei, Neil Brockdorff, Asifa Akhtar, Matthias Merkenschlager
| Nature Verified
Abstract In mammals, chromosome-wide regulatory mechanisms ensure a balance of X-linked gene dosage between males (XY) and females (XX). In female cells, expression of genes from one of the two X chromosomes is curtailed, with selective accumulation of Xist-RNA, Xist-associated proteins, specific histone modifications (for example, H3K27me3) and Barr body formation observed throughout interphase.
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