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Keywords PIGA congenital disorders of glycosylation Drosophila genetic modifier GPI-anchor synthesis incomplete penetrance Get full text access Log in, subscribe or purchase for full access. References 1. Chow, C.Y. Bringing genetic background into focus Nat. Rev. Genet. 2016; 17:63-64 2. Bayat, A. ∙ Knaus, A. ∙ Pendziwiat, M. ... Lessons learned from 40 novel PIGA patients and a review of the literature Epilepsia. 2020; 61:1142-1155 3. Chang, I.J. ∙ He, M.

Keywords Animals, Zika Virus, Zika Virus Infection, Drosophila, Drosophila melanogaster, Microcephaly, Drosophila, Zika virus, Microcephaly, Virus-host targets, Degeneration Abstract In the past decade, Zika virus (ZIKV) emerged as a global public health concern. Although adult infections are typically mild, maternal infection can lead to adverse fetal outcomes.

Abstract Seizures affect a large proportion of the global population and occur due to abnormal neuronal activity in the brain. Unfortunately, widespread genetic and phenotypic heterogeneity contribute to insufficient treatment options. It is critical to identify the genetic underpinnings of how seizures occur to better understand seizure disorders and improve therapeutic development.