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Nick Wareham

As seen in: Nature, The Conversation, The Epoch Times, Inverse, AsiaNet
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Articles by Nick Wareham

Associations of proteomic age clocks with lifestyle risk factors, incident chronic diseases and mortality in two European cohorts

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By Oliver J. Robinson, Han Xiao, Jan Homann, Vivian Viallon, Pietro Ferrari, Philipp Frank, José M. Huerta, Ana Jiménez Zabala, Rudolf Kaaks, Verena A. Katzke, Mika Kivimäki, Claudia Langenberg, Chung-Ho E. Lau, Lefkos T. Middleton, N. Charlotte Onland-Moret, Salvatore Panico, Anna E. Prizment, Fulvio Ricceri, María-José Sánchez, Karl Smith-Byrne, W. M. Monique Verschuren, Roel Vermeulen, Paolo Vineis Verified, Shuo Wang, Nick Wareham, Christina M. Lill, Elio Riboli, Marc J. Gunter
| Nature Verified
Abstract Assessment of biological aging using proteomic clocks may enhance risk prediction and elucidate the molecular links between aging and chronic diseases. Here, among 17,473 participants of the European Prospective Investigation into Cancer and Nutrition, we examined associations of plasma SomaScan-based proteomic clocks, including organ-specific clocks, with risk factors, 24 incident chronic diseases and all-cause mortality, over up to 28 years of follow-up.
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Proteomic analysis of cardiorespiratory fitness for prediction of mortality and multisystem disease risks - Nature Medicine

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By Andrew Perry, Eric Farber-Eger, Tomas Gonzales, Venkatesh L. Murthy, Laura A. Colangelo, Keenan A. Walker, Luigi Ferrucci, Bharat Thyagarajan, Sadiya Khan, Nick Wareham, Claude Bouchard Verified, Mark A. Sarzynski, Robert Gerszten, Soren Brage
| Nature Verified
Abstract Despite the wide effects of cardiorespiratory fitness (CRF) on metabolic, cardiovascular, pulmonary and neurological health, challenges in the feasibility and reproducibility of CRF measurements have impeded its use for clinical decision-making. Here we link proteomic profiles to CRF in 14,145 individuals across four international cohorts with diverse CRF ascertainment methods to establish, validate and characterize a proteomic CRF score.
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Relationship between HLA genetic variations, COVID-19 vaccine antibody response, and risk of breakthrough outcomes - Nature Communications

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By Junqing Xie, Beatriz Mothe, Yu Xu, Shuo Feng, Jia Wei, Zhuoyao Chen, Shenda Hong, Yeda Wu, Catherine Cohet, Nick Wareham
| Nature Verified
Abstract The rapid global distribution of COVID-19 vaccines, with over a billion doses administered, has been unprecedented. However, in comparison to most identified clinical determinants, the implications of individual genetic factors on antibody responses post-COVID-19 vaccination for breakthrough outcomes remain elusive.
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Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease - Nature Genetics

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By Yajie Zhao, Katherine A. Kentistou, Eugene J. Gardner, Katherine Lawler, Felix Day, Lena R. Kaisinger, Hsiao-Jou Cortina Chen, Jaime Berumen-Campos, Pablo Kuri-Morales, Roberto Tapia-Conyer, Jesus Alegre-Díaz, Inês Barroso, Jonathan Emberson, Jason Torres, Katherine Smith, Dirk S. Paul, Florian T. Merkle, Nick Wareham, Slavé Petrovski, Stephen O’Rahilly, Ken Ong
| Nature Verified
Abstract Obesity is a major risk factor for many common diseases and has a substantial heritable component. To identify new genetic determinants, we performed exome-sequence analyses for adult body mass index (BMI) in up to 587,027 individuals. We identified rare loss-of-function variants in two genes (BSN and APBA1) with effects substantially larger than those of well-established obesity genes such as MC4R.
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AsiaNet - View Release

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By Nick Wareham, Their Socio-Economic Consequences
| AsiaNet Verified
Drawbridge Health partners with University of Cambridge Researchers for use of OneDraw(TM) Blood Collection Device in COVID-19 and Other Clinical Studies MENLO PARK, Calif., Dec.
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Eating a Diet Rich in Fruit and Vegetables Daily Lowers Diabetes Risk

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By Nita G Forouhi, Sheng Zheng, Nick Wareham
| The Epoch Times
A large study has found that even small improvement in diet can significantly lower diabetes risk Eating about five servings of fruit and vegetables a day is widely promoted as a key part of a healthy diet. This is because consuming fruit and vegetables is linked to lower risk of health problems such as coronary heart disease, stroke, and some types of cancer. But there’s still confusion about the role that fruit and vegetables have in preventing Type 2 diabetes.
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A diet rich in fruit and vegetables daily lowers risk of this common disease — study

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By Nita G Forouhi, Ju-Sheng Zheng, Nick Wareham
| Inverse Verified
Eating about five servings of fruit and vegetables a day is widely promoted as a key part of a healthy diet. This is because consuming fruit and vegetables is linked to lowering the risk of health problems such as coronary heart disease, stroke, and some types of cancer. But there’s still confusion about the role that fruit and vegetables have in preventing type 2 diabetes.
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Type 2 diabetes: eating a diet rich in fruit and vegetables daily lowers risk, study shows

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By Nita G Forouhi, Ju-Sheng Zheng, Nick Wareham
| The Conversation Verified
Eating about five servings of fruit and vegetables a day is widely promoted as a key part of a healthy diet. This is because consuming fruit and vegetables is linked to lowering the risk of health problems such as coronary heart disease, stroke and some types of cancer. But there’s still confusion about the role that fruit and vegetables have in preventing type 2 diabetes.
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Consumption of soft drinks and juices and risk of liver and biliary tract cancers in a European cohort

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By Magdalena Stepien, Talita Duarte-Salles, Veronika Fedirko, Antonia Trichopoulou, Pagona Lagiou, Christina Bamia, Kim Overvad, Anne Tjønneland, Louise Hansen, Marie-Christine Boutron-Ruault, Guy Fagherazzi, Gianluca Severi, Tilman Kühn, Rudolf Kaaks, Krasimira Aleksandrova, Heiner Boeing, Eleni Klinaki, Domenico Palli, Sara Grioni, Salvatore Panico, Rosario Tumino, Alessio Naccarati, H. Bas Bueno-de-Mesquita, Petra H. Peeters, Guri Skeie, Elisabete Weiderpass, Christine L. Parr, José Quirós Verified, Genevieve Buckland, Esther Molina-Montes, Pilar Amiano, Maria-Dolores Chirlaque, Eva Ardanaz, Emily Sonestedt, Ulrika Ericson, Maria Wennberg, Lena Maria Nilsson, Kay-Tee Khaw, Nick Wareham, Kathryn E. Bradbury, Heather A. Ward, Isabelle Romieu, Mazda Jenab
| Journal of Banking Regulation Verified
The aim of the study was to assess associations between intake of combined soft drinks (sugar sweetened and artificially sweetened) and fruit and vegetable juices and the risk of hepatocellular carcinoma (HCC), intrahepatic bile duct (IHBC) and biliary tract cancers (GBTC) using data from the European Prospective Investigation into Cancer and Nutrition cohort of 477,206 participants from 10 European countries. After 11.4 years of follow-up, 191 HCC, 66 IHBC and 236 GBTC cases were identified.
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