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Articles by Ning Chang
Identification of compounds that repress DUX4 expression in facioscapulohumeral muscular dystrophy
Abstract Facioscapulohumeral muscular dystrophy (FSHD) is caused by epigenetic dysregulation of the disease locus, leading to pathogenic misexpression of DUX4 in skeletal muscle. Thus, most FSHD therapeutic approaches target DUX4. Our previous study identified the chromatin remodeling factor BAZ1A (bromodomain adjacent to zinc finger domain protein 1A) as a promising target for therapeutic development.
'Everybody to Kenmure Street' wants you to be a good neighbour
What happens when a community “doesn’t wait for permission to do the right thing?” This is the question that Everybody to Kenmure Street, a new documentary from Felipe Bustos Sierra, attempts to answer.
Digital Inclusive Finance, Spatial Spillover and Regional Consumption Inequality Mitigation in China: A Perspective From the Consumption Potential Release
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available in the Chinese provincial and municipal statistical yearbooks (2012–2022) and the China Regional Financial Operation Report (2011–2021). Supporting Information Filename Description grow70119-sup-0001-suppl-data.docx277.2 KB Supporting Information S1 References , , and . 2019.
To fix rape culture, we need more options than silencing or sentencing
CW: discussion of sexual assault and gender-based violence It’s been 20 years since the beginning of the #MeToo movement, and 10 since it exploded into a mainstream reckoning: a wave of collective action sweeping Hollywood, academia, and the halls of political power. Looking back, #MeToo has been a watershed moment in exposing just how pervasive rape culture is at all levels of society, and it paved the way to break the suffocating stigmas that kept survivors silent.
Heated Rivalry owes its success to unexpected allies
Not an economist here, but Canada’s biggest export of 2025 isn’t lumber, or oil, or any of that other boring crap. It’s Heated Rivalry.
Revolutionary (Wet) Dreams
What is the Venn diagram overlap between hardened movement organisers and readers of sultry, bodice-ripping fiction? Not a question that has ever previously crossed my mind, but now, dear reader, I have the answer – it’s at least one person, set on recruiting more. Well-known as a leader in the movement for climate and democracy, Keya Chatterjee became the Executive Director of the US Climate Action Network after a stint at NASA, USAID and WWF monitoring our changing climate.
That’s My Mayor!
Zohran Mamdani. The name on the lips of cabbies, college students, investment bankers, bodegueros, Asian aunties, tenant organisers, the governor of Florida and the President of the United States. A State Assembly member from Queens who, in a sprint of just over a year, swathed the city of New York in a shamelessly progressive mayoral campaign infused with joy, bold ideas, and a fighting spirit. And now, after a historic election win, Zohran Mamdani finds himself on the threshold of City Hall.
Dawn to dusk in Liberty City
It’s 6am on a clear day in Downtown Manhattan, with a brisk wind blowing that smells like early fall. In a corner of Thomas Paine Park, volunteers* are setting up chairs and tables. They bring fresh, warm food and coffee. Several of them grab wrapped sandwiches and hand them out to people slowing down, curious as to what’s happening. “Yeah, for free!” they insist. “And while you’re here, do you know your rights?” This is Liberty City.
H2O2‐Dependent Methyl Jasmonate Regulates H2S‐Induced Resistance to Fusarium oxysporum f. sp. niveum Race 2 in Citrullus lanatus
Conflicts of Interest The authors declare no conflict of interest. Supporting Information Filename Description pce15654-sup-0001-Supplementary_Figure_S1-S4.docx121.7 KB Supporting Figure S1-S4. pce15654-sup-0002-Supplementary_Table_S1.docx21.1 KB Supporting Table S1. References , , and . 2023. “RBOHF Activates Stomatal Immunity by Modulating Both Reactive Oxygen Species and Apoplastic pH Dynamics in Arabidopsis.” Plant Journal 116: 404–415. , , , et al. 2022.
The carbon characteristics of digital economy: a case study in China
Advanced search Applied Economics Latest Articles Submit an article Journal homepage Full Article Figures & data References Supplemental Citations Metrics Reprints & Permissions Read this article /doi/full/10.1080/00036846.2025.2501353?needAccess=true ABSTRACT The digital economy is an important area for global economic development, and its carbon emission characteristics are in the spotlight.
Micro-region transcriptomics profiling of cerebral organoids using a capillary-based microdissection system
Micro-region transcriptomics profiling of cerebral organoids using a capillary-based microdissection system Investigating the transcriptome while preserving cellular spatial information facilitates a comprehensive understanding of cellular fates in multicellular organisms. However, the precise and flexible isolation of micro-regions of interest (mROIs) for profiling spatial transcriptomics (ST) remains a challenge.
“Carrying the torch” of a queer country renaissance
It’s a weeknight in New York City. The cowboys, cowgirls, and cowpokes are making their way down the subway platforms, boots knocking, bandanas ruffling in the wind, to dance. Whether in a restaurant backroom, a studio in the Garment District, a warehouse in Ridgewood, or a bowling hall in Brooklyn, outposts of western country dancing have cropped up in pockets of the Big Apple.
Simultaneously Achieved High Piezoelectricity and High Resistivity in Na0.5Bi4.5Ti4O15-Based Ceramics with High Curie Temperature
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“A place where ghosts are alive”: One community’s reckoning with Canada’s residential school system
“This is a community living on the edge of death,” Sugarcane co-director Julian Brave NoiseCat tells me over Zoom. A passionate activist, prolific journalist of North American Indigenous life, and newly-minted filmmaker, Julian is one of most credible people to make that conclusion mainly because the community he’s talking about is his own.
Herman Yau on ‘Customs Frontline’ and How He Shoots Action Films: Extensive Preparation, Rapid Filming
By Daniel Eagan Maybe you thought the golden age of Hong Kong cinema had hung up its gloves…Think again! Herman Yau’s still around to deliver a knockout punch to that notion. Yau isn't just busy – he's a filmmaking cyclone.
Odyssey Years: Can the ‘Hidden Corner’ speak?
One of my fellow spring columnists, Nicholas Baum, writes a column called Hidden Corners of New York City, covering what he feels are the unexplored places and histories of the Big Apple. While this invitation to visit interesting parts of the city isn’t altogether unwelcome—I, too, hope that people will learn about how much this city has to offer—the tone and approach of his column have always bugged me slightly.
Odyssey Years: Mega Millions and other Superstitions
Last Wednesday, my friend Melanie and I stopped by a convenience store on 108th Street to buy our vices—American Spirits for her, a lottery ticket for me.
American Girl doll
I spend a lot of time hanging out with one of my best friends, Bella. We know each other from high school, and we share a lot of touchstones from growing up in New York City’s private school system.
A Valentine for the fool on the hill
When my partner and I walk around the Upper East Side, we always look through the windows of the late 19th-century townhouses that dot the quiet streets. We peer past the classic facades, stoops, and little gardens to the stained glass in the entryways or the wallpaper in the living rooms, pointing out the details we like best. Just before Valentine’s Day, my partner and I were walking up the hill toward Central Park when something made me stop in my tracks and grab his arm. Was that… a man?
Can we all agree that the TikTok aesthetic machine is out of order?
It’s the newest marketing of a centuries-old hegemonic patriarchal agenda. And while agenda can feel like a strong word to describe “mob wives” and such, it is the right word. Picking an argument over “office sirens” as a feminist issue becomes something I take “too seriously” for ascribing feminist warning bells to something as simple as internet-oriented fancy-dress. It’s the newest marketing of a centuries-old hegemonic patriarchal agenda.
Can we all agree that the TikTok aesthetic machine is out of order?
If you think about the abiding trends and traits of each decade or generation, the Gen Xers in the 80s had their era of perms and their neon; the millennials in the aughts and teens had their era of whale tails and their indie sleaze, and now we have our era of eras. Much has already been written about the rapidly cycling nature of trends and microtrends, and how they reflect our particular brand of late-stage capitalism.
Confessions of a former Barbie girl
Like a lot of other sustainability-minded people, I always felt guilty about my habits of consumption. I wondered if I should spend more money on stuff that is eco-friendly or “green,” if what I was buying had been “greenwashed,” and then, if I bought clothes that were less green, but wore them for longer, was it more green?
Confessions of a former Barbie girl
Like a lot of other sustainability-minded people, I always felt guilty about my habits of consumption. I wondered if I should spend more money on stuff that is eco-friendly or “green,” if what I was buying had been “greenwashed,” and then, if I bought clothes that were less green, but wore them for longer, was it more green?
Odyssey Years: A prelude to our journey
In The Game of Life, players spin a wheel to move across colored tiles to simulate adult life, whizzing around the board represented by a little plastic peg in the front seat of a little plastic car. At the start of the game, you choose between college and a career. Later, you hit a junction on a red tile and you have to make an important decision about your job, marriage, or house.
Odyssey Years: A prelude to our journey
In The Game of Life, players spin a wheel to move across colored tiles to simulate adult life, whizzing around the board represented by a little plastic peg in the front seat of a little plastic car. At the start of the game, you choose between college and a career. Later, you hit a junction on a red tile and you have to make an important decision about your job, marriage, or house.
South Africa just filed a case with the ICJ accusing Israel of “genocidal acts,” but what does this mean?
South Africa filed a case with the ICJ accusing Israel of “genocidal acts,” but what does this mean?
South Africa just filed a case with the ICJ accusing Israel of “genocidal acts,” but what does this mean?
On Friday 29th December, South Africa filed an application with the International Court of Justice (ICJ) requesting urgent action on the violence in Gaza, accusing Israel of violating the 1948 Genocide Convention and committing “genocidal acts.” When the news broke, I, like so many people, felt a sense of relief. It felt like an international authority was finally taking notice, and there would be greater potential for a sustainable peace and an end to the escalating violence.
A novel mucosal bivalent vaccine of EV-A71/EV-D68 adjuvanted with polysaccharides from Ganoderma lucidum protects mice against EV-A71 and EV-D68 lethal challenge | Journal of Biomedical Science | Full Text
In this study, the EV-A71 strain TW/2272/98 (C2 genogroup) for the purification of the inactivated EV-A71 vaccine was kindly provided by Prof. Shin-Ru Shih, at the Research Center for Emerging Viral Infections, Chang Gung University, Taiwan. EV-D68 (CDC_NO 2010-01788), in Clade B3, was used as the vaccine antigen.
Knots of Memory - Columbia Daily Spectator
December 10, 2023, 3:06 PM By Gabe de la Cruz / Staff Illustrator Last summer, my grandmother opened the family safe to show us her gold jewelry. In between bracelets and earrings, there were two chunks of gold that she said my great-great-grandmother had sewn into her clothing to keep safe as she migrated overseas. They came from a time when emperors ruled China and are stamped with Chinese characters I couldn’t understand.
Journalists must uphold their commitment to truth
On October 12, a huge crowd assembled on the east side of South Lawn to show support for Palestinians. As helicopters hovered over campus, student leaders held a moment of silence honoring all victims of violence, led peaceful chants, and gave powerful speeches advocating for the rights and dignity of all those affected by Israeli occupation. But this is not the story that the media told.
Forest Fire Spread Hazard and Landscape Pattern Characteristics in the Mountainous District, Beijing
3.3. Correlation Analysis of the Forested Landscape Spatial Pattern and Forest Fire Spread Hazard in the Mountainous District of Beijing 3.3.1. Calculation and Statistics of the Landscape Pattern Index of Townships in the Mountainous District of Beijing At the landscape level, eleven indices, including TA, NP, PD, LPI, LSI, CONTAG, DIVISION, PR, PRD, SHDI, and AI, were selected to calculate the forest landscape spatial pattern characteristics of townships in the Mountainous District of Beijing.
12 Weeks is not an Abortion Film
12 Weeks is about Alice, a successful, career-oriented 40-year-old who grapples with an unexpected pregnancy, its impact on her life and interpersonal relationships, while also seeking an illegal abortion in the strongly Catholic country. Yet, Sunshine resists defining 12 Weeks as an abortion film – the label is too “sensationalist” and “festival bait” – to her, the film is more so about modern womanhood in the Philippines.
Fine-tuning FAM161A gene augmentation therapy to restore retinal function
Abstract In 15 years, inherited retinal diseases have seen gene therapy as a springboard to hope. Many preclinical investigations focused on vectors with maximal gene expression capabilities. But despite an efficient gene transfer, little physiological improvement was noted for certain ciliopathies. FAM161A is an essential protein for the structure of photoreceptor connecting cilium (CC). In the absence of FAM161A, cilia disorganize resulting in outersegment collapses and vision impairment.
Changing the culture of kill in “Chain-Gang All-Stars”
It is not a stretch to say that the hyper-carceral, hyper-capitalist world of Loretta and Hamara is just a few steps from our own. “It’s really just a slight extrapolation against where we already are,” Nana observes as we chat over Zoom.
12 Weeks is not an Abortion Film
In the late afternoon of one of this summer’s hottest days on record, I sat down for a conversation with writer and director Anna Isabelle “Sunshine” Matutina. 12 Weeks, her first feature film, was premiering internationally in this year’s New York Asian Film Festival at Lincoln Center in New York City. Sunshine is a whirlwind of energy in a bright pink top and a chic pixie cut – it was hard to believe she had stepped off a flight from the Philippines less than 12 hours earlier.
Imaging Characteristics of Disturbance Flow Field Surrounding a Hypersonic Target
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There is no Asian American dream without affirmative action
Last month, the Supreme Court ruled 6-3 to strike down race-conscious affirmative action policies as unconstitutional and discriminatory.
Changing the culture of kill in “Chain-Gang All-Stars”
We open in a roaring crowd, in a stadium packed to the rafters with a wash of humanity, and a single woman in the eye of the hurricane. She is Loretta Thurwar, and this is the heart-pounding start of Chain-Gang All-Stars, the debut novel by author Nana Kwame Adjei-Brenyah.
“Eat, Pray, Love” reconsidered
One aspect of being Southeast Asian in America that nobody tells you about is the ubiquity of
American Girl doll
I spend a lot of time hanging out with one of my best friends, Bella. We know each other from high school, and we share a lot of touchstones from growing up in New York City’s private school system.
“We Are Sharing the Same Space, Yet We Are So, So Apart.”
I first cracked open Invisible Child on the C train, shuttling up and down the West Side between my home and my workplace. There was something about the lulling anonymity, the feeling of being whisked between the different corners of the city in a subway setting, that allowed me to sink into the different side of New York City that Andrea Elliott weaves around the story of Dasani Coates, an 11 year old growing up in the shelter system in New York.
Global inhibition in head-direction neural circuits: a systematic comparison between connectome-based spiking neural circuit models
New Results doi: https://doi.org/10.1101/2023.02.03.526928 Abstract The recent discovery of the head-direction (HD) system in fruit flies has provided unprecedented insights into the neural mechanisms of spatial orientation. Despite the progress, the neural substance of global inhibition, an essential component of the HD circuits, remains controversial. Some studies suggested that the ring neurons provide global inhibition, while others suggested the Δ7 neurons.
Being the Rabbit - Columbia Spectator
Editor's Note: This article deals with topics of anti-Asian violence.
Cross-sectional Neuromuscular Phenotyping Study of Patients With Arhinia With SMCHD1 Variants
Cross-sectional Neuromuscular Phenotyping Study of Patients With Arhinia With SMCHD1 Variants Payam Mohassel, Ning Chang, Kaoru Inoue, Angela Delaney, Ying Hu, Sandra Donkervoort, Dimah Saade, B. Jeanne Billioux, Brooke Meader, Rita Volochayev, Chamindra G. Konersman, Angela M. Kaindl, Chie-Hee Cho, Bianca Russell, Adrian Rodriguez, K. Wade Foster, A. Reghan Foley, Steven A. Moore, Peter L. Jones, Carsten G. Bonnemann, Takako Jones, Natalie D.
A Valentine for the fool on the hill
When my partner and I walk around the Upper East Side, we always look through the windows of the late 19th-century townhouses that dot the quiet streets. We peer past the classic facades, stoops, and little gardens to the stained glass in the entryways or the wallpaper in the living rooms, pointing out the details we like best. Just before Valentine’s Day, my partner and I were walking up the hill toward Central Park when something made me stop in my tracks and grab his arm. Was that… a man?
Physical Properties and Its Estimation of Binary Mixtures of Ether-Functionalized Ionic Liquids [C22O1IM][NTF2] with Alcohols
The binary mixtures composed of 1-ethyl-3-(2-methoxyethyl)-imidazolium bis(trifluoromethylsulfonyl)imide [C22O1IM][NTF2] and alcohols were prepared, and the density and viscosity were measured first across the entire range of mole fraction within a particular temperature range. Based on the experimental values of density, the average molar volume, the excess molar volume, and the partial molar volume were calculated, and the excess molar volume was well fitted by Redlich–Kister equation.
Extracellular vesicle-associated VEGF-C promotes lymphangiogenesis and immune cells infiltration in endometriosis
Extracellular vesicle-associated VEGF-C promotes lymphangiogenesis and immune cells infiltration in endometriosis Wan-Ning Li, Kuei-Yang Hsiao, Chu-An Wang, Ning Chang, Pei-Ling Hsu, Chung-Hsien Sun, Shang-Rung Wu, Meng-Hsing Wu, Shaw-Jenq Tsai Proceedings of the National Academy of Sciences Oct 2020, 201920037; DOI: 10.1073/pnas.1920037117
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