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Articles by Ningning Ma
HK2 drives synaptic dysfunction in fragile X syndrome via epigenetic regulation of H3K18 lactylation
Abstract Introduction: Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by loss of fragile X messenger ribonucleoprotein (FMRP) expression and characterized by synaptic dysfunction and cognitive impairment. However, the metabolic and epigenetic mechanisms underlying these abnormalities remain poorly understood.
Age-related degeneration initiates at the surface: preferential biomechanical and biological decline in rat articular cartilage
Abstract Age-related degeneration of articular cartilage is a key pathological hallmark of primary osteoarthritis (OA). As the cartilage’s barrier layer, the superficial zone maintains tissue homeostasis and is increasingly recognized as the initial site of age-related cartilage degeneration. Disruption of this zone exposes deeper layers to hostile microenvironments, accelerating pan-cartilaginous changes; however, its age-related progression remains incompletely defined.
MCT4 deficiency suppresses tumor incidence and metastasis by downregulating IGF1 expression and enhancing anti-tumor immunity
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Abstract Monocarboxylate transporter 4 (MCT4/SLC16A3) is frequently upregulated in human cancers and associated with aggressive progression and poor clinical outcomes. To elucidate its functional role, we establish MCT4 homozygous knockout BALB/c mice (MCT4-/-) using CRISPR/Cas9-EGE technology.
By Shuo Wang, Hailing Guo, Xinyi Wang, Yujie Zhang, Xin Li Verified, Xiaoju Zhou, Ningning Ma, Lujin Feng
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Nature
Verified
A new device and method for detecting the permeability of articular cartilage
Abstract Objective: Articular cartilage relies on synovial fluid for substance exchange, with permeability being a key parameter linked to its physiological functions and degenerative disease mechanisms. Existing detection techniques are limited by detachment from physiological mechanical environments, insufficient quantification accuracy, and poor sealing. This study aimed to develop an accurate, reliable, and physiologically relevant device and method for cartilage permeability detection.
The essential role of heparan sulfate in the entry of PDCoV and other porcine coronaviruses
ABSTRACT Porcine enteric coronaviruses, including porcine deltacoronavirus (PDCoV), porcine epidemic diarrhea virus (PEDV), swine acute diarrhea syndrome coronavirus (SADS-CoV), and transmissible gastroenteritis coronavirus (TGEV), can cause acute diarrhea, vomiting, dehydration, and high mortality in suckling piglets.
Optimizing Spring Maize Growth and Yield through Balanced Irrigation and Nitrogen Application: A TOPSIS Method Approach
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Optimizing Spring Maize Growth and Yield through Balanced Irrigation and Nitrogen Application: A TOPSIS Method Approach
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 17 June 2024 / Approved: 17 June 2024 / Online: 17 June 2024 (08:12:34 CEST) Liu, Y.; Gu, J.; Ma, N.; Li, X.; Yin, G.; Sun, S. Optimizing Spring Maize Growth and Yield through Balanced Irrigation and Nitrogen Application: A TOPSIS Method Approach. Preprints 2024, 2024061117. https://doi.org/10.20944/preprints202406.1117.v1 Liu, Y.; Gu, J.; Ma, N.; Li, X.; Yin, G.; Sun, S.
Unsupervised Deep Anomaly Detection for Industrial Multivariate Time Series Data
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Confinement in Dual-Chain-Locked DNA Origami Nanocages Programs Marker-Responsive Delivery of CRISPR/Cas9 Ribonucleoproteins
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2023, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Water | Free Full-Text | Estimation of Spring Maize Evapotranspiration in Semi-Arid Regions of Northeast China Using Machine Learning: An Improved SVR Model Based on PSO and RF Algorithms
2.4. Particle Swarm Optimization Algorithm The particle swarm optimization (PSO) algorithm is a stochastic heuristic optimization algorithm that simulates the foraging behavior of bird populations, developed by Kennedy, et al. [45], and is applied to solving function optimization problems. The PSO algorithm has excellent global search and optimization abilities, and has been widely used in the parameter optimization of various machine learning models [46].
Low-entropy lattices engineered through bridged DNA origami frames
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Low-entropy lattices engineered through bridged DNA origami frames
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Enhancing physicochemical stability and digestibility of DHA emulsions by encapsulation of DHA droplets in caseinate/alginate honeycomb-shaped microparticles
Enhancing physicochemical stability and digestibility of DHA emulsions by encapsulation of DHA droplets in caseinate/alginate honeycomb-shaped microparticles Docosahexaenoic acid (DHA) was encapsulated in caseinate/alginate microparticles by adjusting the pH based on the electrostatic complexation, in order to improve its physicochemical stability and digestibility of the single caseinate-stabilized DHA emulsions.
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