Amy R. Nippert
Minnesota
Postdoc studying chronic pain. Enjoys weird fiction and bad puns. She/her.
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Articles by Amy R. Nippert
Neurovascular coupling is preserved in the cerebral cortex of diabetic mice: A longitudinal study
Get full access to this article View all access and purchase options for this article. Data availability statement The data that support the findings of this study and the MATLAB routines used to analyze the data are available from the corresponding author upon reasonable request. References 1. Akbari CM, LoGerfo FW. Diabetes and peripheral vascular disease. J Vasc Surg 1999; 30: 373–384. 2. Ravshanovna SD. Morphological appearance of blood vessels of organs in diabetes mellitus.
Ethological profiling of pain and analgesia in a mouse model of complex regional pain syndrome.
Abstract Complex regional pain syndrome (CRPS) is a form of chronic post-injury pain affecting the extremities. The mouse tibial fracture-cast model was developed to enable preclinical study of CRPS mechanisms and guide condition-specific drug development. Given the inherent limitations of reflex pain measures in mice, we sought to characterize pain-like behaviors in this model more holistically.
Repopulated spinal cord microglia exhibit a unique transcriptome and contribute to pain resolution
Highlights • Selective depletion and repopulation of microglia completely reverse pain-like sensitivity • Reversal in pain trajectory coincides with microglial repopulation, not depletion • Repopulated microglia transcriptomes show active environmental surveillance after injury • Microglial genes are validated by intersection with human lumbar spinal cord microglial genes Summary Microglia are implicated as primarily detrimental in pain models; however, they exist across a continuum of states...
Putting a Pause on Pain: Chemogenetic Silencing of NaV1.8-Positive Sensory Neurons
chemogenetics DRG NaV1.8 pain sensory The sensory system allows humans to not only explore the world but also to monitor their own bodies for injury and disease through the sensation of pain. After an injury, signals from the injured tissues travel along the nerves, entering the central nervous system through the spinal cord before going into the brain. In the acute stages, pain modulates behavior in ways that promote healing, including limiting mobility.
Whisker-evoked neurovascular coupling is preserved during hypoglycemia in mouse cortical arterioles and capillaries
Get full access to this article View all access and purchase options for this article. Data availability statement The data that support the findings of this study and the MATLAB routines used to analyze the data are available from the corresponding author upon reasonable request. References 1. Raichle ME. The restless brain: how intrinsic activity organizes brain function. Phil Trans R Soc B 2015; 370: 20140172. 2. Attwell D, Buchan AM, Charpak S, et al. Glial and neuronal control of brain blood flow.
Newly repopulated spinal cord microglia exhibit a unique transcriptome and correlate with pain resolution
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Learning from the policy world to give a voice to science
If we’re to give a voice to science and society, we mustn’t forget the role of lawmakers – and the communication lessons they can provide. I’ve blogged a lot about science policy and how to get involved at the Fancy Comma blog. I’ve talked about being a scientist in politics, ways scientists can get involved in science policy, and more. Check out all our science policy posts geared toward scientists seeking to get involved in the policy world.
Spatial Organization and Dynamics of the Extracellular Space in the Mouse Retina
Cover ArticleResearch Articles, Cellular/Molecular Sidney P. Kuo, Pei-Pei Chiang, Amy R. Nippert and Eric A. Newman Journal of Neuroscience 7 October 2020, 40 (41) 7785-7794; DOI: https://doi.org/10.1523/JNEUROSCI.1717-20.2020 Abstract The extracellular space (ECS) plays an important role in the physiology of neural circuits. Despite our detailed understanding of the cellular architecture of the mammalian retina, little is known about the organization and dynamics of the retinal ECS.
Spatial Organization and Dynamics of the Extracellular Space in the Mouse Retina
Research Articles, Cellular/Molecular Sidney P. Kuo, Pei-Pei Chiang, Amy R. Nippert and Eric A. Newman Journal of Neuroscience 4 September 2020, JN-RM-1717-20; DOI: https://doi.org/10.1523/JNEUROSCI.1717-20.2020 Abstract The extracellular space (ECS) plays an important role in the physiology of neural circuits. Despite our detailed understanding of the cellular architecture of the mammalian retina, little is known about the organization and dynamics of the retinal ECS.
Methamphetamine can ferry other drugs across the blood-brain barrier
Get new Lab Notes sent to your inbox Paper wasps (Polistes fuscatus) are very good at recognizing and remembering individual faces. In the spring, sexually mature females, known as “foundresses,” race to secure a nest site which they may maintain either alone or alongside a coterie of co-foundresses with whom they share brood space. For a given foundress to cooperate with her allies and thwart potential usurpers, she must be able to recognize individual wasps as distinct entities.
Slow progress towards treatment of sickle cell anemia
By Amy Nippert Kevin Wake was 9 months old when he was diagnosed with sickle cell anemia. Since then, the 52-year-old has had two strokes and receives blood transfusions every five weeks to reduce the chances of having a third. His repeated pain crises mean frequent trips to the emergency room. Wake’s disease is the result of a genetic mutation that causes a person’s red blood cells to deform and carry oxygen poorly, leading to blocked vessels, organ damage, and pain.
Your language brain matters more for learning programming than your math brain
Christina Morillo on Wikimedia Commons. New research contradicts long held assumptions about coding May 12, 2020 When you think of learning another language, you probably think of French, Spanish, or Chinese. But what about Python or Java? The two processes might be more similar than you'd think.
How a Scientific Reserve Corps could help us in a pandemic
After the World Health Organization (WHO) declared that the coronavirus outbreak is officially a pandemic, countries around the world have responded accordingly. Universities in Canada and the US are closing, non-essential conferences and sports leagues are being canceled, and people are being advised to halt all travel plans. Anyone can get infected, and the only way to slow down the outbreak is to reduce the number of people getting infected.
Connecting brains to machines may let bacteria come along for the ride
(Getty/Just_Super) Brain-machine interfaces like Elon Musk’s Neuralink have come a long way, but biological limitations remain Amy Nippert December 18, 2019 9:59AM (UTC) This story originally appeared on Massive Science, an editorial partner site that publishes science stories by scientists. Subscribe to their newsletter to get even more science sent straight to you.
Connecting brains to machines may let bacteria come along for the ride
NASA/Sean Smith Brain-machine interfaces like Elon Musk's Neuralink have come a long way, but biological limitations remain December 15, 2019 Devices that record and interpret brain activity to control machines, known as brain-machine interfaces (BMIs), are rapidly moving from science fiction to potential reality. One that you may have heard of is Neuralink, a company owned by Elon Musk.
Science articles written by science perform as well as those written by journalists
It's easy to give thoughtless gifts. This year, give thoughtful gifts: science gifts! They're experimentally validated as wonderful*. This is Massive's 2019 holiday science shopping guide, with cool stuff from all around the science web, for Thanksgiving, Black Friday, Christmas, and beyond. Illustrated by Matteo Farinella, Designed by Allan Lasser Massive Science Oh wow, so weird to see us at the top here. The coolest thing on this list is definitely the Women of Science Tarot deck we made.
The replication crisis and its zombies are a student's worst nightmare
Get new Lab Notes sent to your inbox Submit a note Submit your own Lab Note Share an interesting science story or tell a short one of your own Ed: All this week Massive is marking Halloween with stories of scary, witchy, and downright ghastly stories from nature. If you walk around an old cemetery, you might notice tombstones that have sunk into the dirt, tilted to the side, or even appeared to move across the ground since they (and their owners) were first placed.
Keeping the Brain Well Fed: The Role of Capillaries and Arterioles in Orchestrating Functional Hyperemia
To use the Enhanced view of this article, please enable JavaScript on in your browser and refresh the page. PreviewKeeping the Brain Well Fed: The Role of Capillaries and Arterioles in Orchestrating Functional Hyperemia © 2018 Elsevier Inc.
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