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Niying Chua on Muck Rack

Niying Chua

As seen in: Nature
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Articles

Mining of natural diversity enables efficient and expressible peptide asparaginyl ligases

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By Wenyu Du, Shi Qi, Mingming Zhen, Miao Liao, Yang Zhao, Jiahui Ma, Yining Hao, Hui Jiang, Chong Wai Liew, Niying Chua, Huachao Chen, Xinya Hemu, Gengyu Lu, Guangwan Hu
| Nature Verified
Abstract Peptide asparaginyl ligases (PALs) are powerful tools for protein engineering but are limited by natural rarity and poor expression. We mine 23 cyclotide-rich Viola species, uncovering 29 PALs that expand the known repertoire to 47. A dual-objective screen identifies VdiPAL1 as the best-performed natural PAL, with twice efficiency of wt-VyPAL2 and 12 mg L-1 soluble expression in E. coli.
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Engineering a riboswitch-based genetic platform for the self-directed evolution of acid-tolerant phenotypes

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By Hoang Long Pham, Adison Wong, Niying Chua, Wei Suong Teo
| Nature Verified
The discovery of a 207-nucleotide RNA element that regulates the expression of the alx gene in E. coli in a pH-dependent fashion was previously reported27, 28. This wild-type pH-responsive RNA element (PRE) functions by adopting distinct folding conformations co-transcriptionally to affect mRNA synthesis (Fig. 1a).
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