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Nuri Alpay Temiz

As seen in: Nature, Cell Reports Medicine
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Articles

Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes - Nature Communications

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By Ambrocio Sanchez, Pedro A. Ortega, Ramin Sakhtemani, Lavanya Manjunath, Sunwoo Oh, Elodie Bournique, Kyumin Kim, Cameron Durfee, Nuri Alpay Temiz, Xiaojiang S. Chen, Reuben S. Harris
| Nature Verified
Abstract Antiviral DNA cytosine deaminases APOBEC3A and APOBEC3B are major sources of mutations in cancer by catalyzing cytosine-to-uracil deamination. APOBEC3A preferentially targets single-stranded DNAs, with a noted affinity for DNA regions that adopt stem-loop secondary structures.
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Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases

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By Cameron Durfee, Rena Levin-Klein, Nuri Alpay Temiz
| Cell Reports Medicine Verified
Highlights • Expression of the human DNA deaminase APOBEC3B in mice causes male sterility • Catalytically active APOBEC3B drives accelerated rates of tumor development • APOBEC3B-expressing tumors exhibit signature C-to-T mutations in TCW motifs • APOBEC3B signature enrichment associates positively with increased levels of indels Summary The antiviral DNA cytosine deaminase APOBEC3B has been implicated as a source of mutation in many cancers.
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