Onyekachi E Ononye

Abstract Replication Protein A (RPA), a single-stranded DNA (ssDNA) binding protein, is vital for various aspects of genome maintenance such as replication, recombination, repair and cell cycle checkpoint activation. Binding of RPA to ssDNA protects it from degradation by cellular nucleases, prevents secondary structure formation and illegitimate recombination.

Determining the function of PTMs Finding the function of modifications on any protein can be a long process, even after the writers and erasers of that modification have been identified. We can think about function at 2 levels. The first level focuses on Gcn5 itself. As outlined in Fig 2, there are multiple ways that we can envision modifications direct Gcn5 molecules to unique fates and examples of these have been discussed throughout this review.

Onyekachi E. Ononye1‡, Christopher W. Sausen2‡, Lata Balakrishnan1* and Matthew L. Bochman2* 1Department of Biology, School of Science, Indiana University, Purdue University Indianapolis, Indianapolis, Indiana, USA 2Molecular and Cellular Biochemistry Department, Indiana University, Bloomington, Indiana, USA ↵*For correspondence: Lata Balakrishnan, latabala{at}iupui.edu; Matthew L. Bochman, bochman{at}indiana.edu. ↵‡ These authors contributed equally to this work.