Osama Al Rahma

Discussion In this three-part, phase 1, dose-escalation/dose-expansion study of INCB001158 alone or combined with pembrolizumab, INCB001158 100 mg two times per day was the RP2D for both monotherapy and combination therapy. INCB001158 was generally well tolerated in both monotherapy and combination therapy.

Discussion This study evaluated the role of a TGF-β-inhibiting agent in a heterogeneous population of patients with NSCLC (different tumor histology, PD-L1 expression levels and different prior cancer therapies) who were previously treated with systemic therapies and were either ICI-naïve or ICI-experienced. Bintrafusp alfa showed modest clinical activity and had a manageable safety profile in this population. Treatment responses per IRC were only observed in the ICI-naïve group (ORR, 27.8%).

The COVID-19 has played havoc with all aspects of life, for countries that are the drives of global remittance flows, even more so. Image Credit: Ador T. Bustamante/Gulf News When global economies united in the countdown to welcome a New Year, no one was prepared for what 2020 had in store. Over the past few months, the world has witnessed a surreal phase, as the COVID-19 made a conspicuous attempt to bring economies to a standstill. However, the UAE did not let this hinder its advancement.