Ove Eriksson

Abstract Climate warming is shifting biological communities, with warmth-demanding species being favoured at the expense of cold-adapted species in a process referred to as thermophilization1,2,3,4. Because biodiversity responses often lag behind climate warming, climatic debts are accumulating in many ecosystems across the world5,6,7. Although we might expect that thermophilization and climatic debts will vary among habitats, standardized quantification across ecosystems is lacking.

Research ArticleOnline nowe42031Open access 1Medicum, Department of Biochemistry and Developmental Biology, Faculty of Medicine, P.O. Box 63, FIN-00014 University of Helsinki, Finland 2Minerva Foundation Institute for Medical Research, Biomedicum Helsinki 2U, Tukholmankatu 8, FIN-00290 Helsinki, Finland 3HiLIFE, Meilahti Clinical Proteomics Core Facility, University of Helsinki, Helsinki, Finland 4Institute of Chemistry, University of Tartu, Ravila 14a, 50411, Tartu, Estonia 5Institute of...

Abstract Ubiquitin specific protease-14 (USP14) is critical for controlling protein homeostasis disturbed in human disorders like Parkinson′s disease (PD). Here we investigated the role of USP14 in regulating proteasome and autophagy pathways, and their influence on α-synuclein (α-syn) degradation. Data showed that α-syn and phosphorylated serine129 α-syn (pS129 α-syn) were elevated in USP14 gene deleted SH-SY5Y dopaminergic cells with concomitant reduction in proteasome activity.