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Owen Wilkins

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Articles

CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies

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By Owen Wilkins, Matthew H. Ung, Scott Bang, William W. Feng
| Cell Reports
Highlights • Lapatinib-resistant breast cancer cells upregulate CD36 expression for survival • Targeting CD36 re-sensitizes lapatinib-resistant cells to HER2-inhibition • Deletion of Cd36 significantly attenuates MMTV-neu-driven mammary tumor growth • CD36 is induced by HER2-targeted therapy and predicts poor clinical prognosis Summary Although it is established that fatty acid (FA) synthesis supports anabolic growth in cancer, the role of exogenous FA uptake remains elusive.
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