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1Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA 2Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston TX 77030 3Department of Pediatrics, Division of Medical Genetics and Genomic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA 4School of Psychology, University of Houston, Houston, TX, USA 5Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA 6Department of Pediatrics,...
Abstract Infection by yellow fever virus (YFV), the prototype Orthoflavivirus, induces a febrile syndrome in humans that can progress to liver failure, haemorrhage and death1. Despite decades of study, the entry receptors for YFV remain unclear. Here, using a surface protein-targeted CRISPR–Cas9 screen, we identified LRP4, a low-density lipoprotein receptor (LDLR) family member, as a candidate entry receptor for YFV.
Abstract Human astroviruses (HAstV) are major causes of gastroenteritis, especially in children, and there are no vaccines or antivirals currently available. Little is known about host factors required for their cellular entry. Here we utilized complementary CRISPR-Cas9-based knockout and activation screens to identify neonatal Fc receptor (FcRn) and dipeptidyl-peptidase IV (DPP4) as entry factors for HAstV infection in vitro.
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