Parashar Dhapola on Muck Rack

Parashar Dhapola

As seen in: Cell Press, Cell Reports, eLife
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Articles

Single-cell multiomics analysis of chronic myeloid leukemia links cellular heterogeneity to therapy response

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By Rebecca Warfvinge, Linda Geironson Ulfsson, Parashar Dhapola, Fatemeh Safi
| eLife
eLife assessment This study presents fundamental insights into the heterogeneity of chronic myeloid leukemia (CML) stem cells and their response to tyrosine kinase inhibitor therapy, shedding light on potential mechanisms underlying treatment failure. The study's robust methodology, supported by validation with bulk RNA-seq data and surface marker analysis, provides compelling evidence for the identified associations between cellular composition and treatment outcome.
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Single cell multi-omics analysis of chronic myeloid leukemia links cellular heterogeneity to therapy response

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By Rebecca Warfvinge, Parashar Dhapola, Fatemeh Safi, Linda Geironson Ulfsson
| biorxiv.org
Abstract The advent of tyrosine kinase inhibitors (TKIs) as treatment of chronic myeloid leukemia (CML) is a paradigm in molecularly targeted cancer therapy. Nonetheless, TKI insensitive leukemia stem cells (LSCs) persist in most patients even after years of treatment. The sustained presence, heterogeneity and evolvability of LSCs are imperative for disease progression as well as recurrence during treatment-free remission (TFR).
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Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age

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By Anna Konturek-Ciesla, Parashar Dhapola, Qinyu Zhang, Petter Säwén
| Cell Reports Verified
Antibodies CD11b - APC (clone M1/70) Sony Biotechnology Cat# 1106060; RRID: N/A CD11b - Biotin (clone M1/70) Sony Biotechnology Cat# 1106020; RRID: N/A CD11c - Biotin (clone N418) eBioscience Cat# 13-0114-85; RRID: AB_466364 CD117 - APC (clone 2B8) Sony Biotechnology Cat# 1129060; RRID: N/A CD117- APC/eFluor 780 (clone 2B8) eBioscience Cat# 47-1171-82; RRID: AB_1272177 CD127 - Biotin (clone A7R34) Sony Biotechnology Cat# 1275030; RRID: N/A CD135 - Biotin (clone A2F10) eBioscience Cat#...
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