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Articles by Pascal Chappert
Affinity-matured B cell responses neutralizing type-I interferons underlie severe viral infections
Keywords type-I interferon B cells antibodies COVID-19 autoimmunity Sars-CoV-2 affinity maturation memory B cells severe viral infections Get full text access Log in, subscribe or purchase for full access. References 1. Crow, Y.J. ∙ Casanova, J.-L. Human life within a narrow range: The lethal ups and downs of type I interferons Sci. Immunol. 2024; 9, eadm8185 2. Bastard, P. ∙ Gervais, A. ∙ Le Voyer, T. ...
Human anti-smallpox long-lived memory B cells are defined by dynamic interactions in the splenic niche and long-lasting germinal center imprinting
Aibar S. González-Blas C.B. Moerman T. Huynh-Thu V.A. Imrichova H. Hulselmans G. Rambow F. Marine J.-C. Geurts P. Aerts J. et al. SCENIC: single-cell regulatory network inference and clustering. Nat. Methods. 2017; 14: 1083-1086https://doi.org/10.1038/nmeth.4463 Akondy R.S. Fitch M. Edupuganti S. Yang S. Kissick H.T. Li K.W. Youngblood B.A. Abdelsamed H.A. McGuire D.J. Cohen K.W. et al. Origin and differentiation of human memory CD8 T cells after vaccination. Nature.
Rituximab-resistant splenic memory B cells and newly engaged naive B cells fuel relapses in patients with immune thrombocytopenia
B cells behaving badly Patients diagnosed with B cell–mediated autoimmune diseases, such as immune thrombocytopenia (ITP), can benefit from treatment with the B cell–depleting antibody, rituximab. Unfortunately, a large proportion of patients relapse after treatment. To understand why, Crickx et al. evaluated B cell phenotypes and specificity, finding two populations of B cells that may contribute to such relapses.
Maturation and persistence of the anti-SARS-CoV-2 memory B cell response
Highlights • Seasonal coronavirus memory B cells contribute to the early anti-SARS-CoV-2 response • Spike-specific memory B cells with a resting phenotype increase up to 6 months • Somatic mutations accumulate in SARS-CoV-2-specific memory B cells over time • Longitudinal study reveals a temporal switch to anti-RBD neutralizing memory B cells Summary Memory B cells play a fundamental role in host defenses against viruses, but to date, their role has been relatively unsettled in the context of...
Maturation and persistence of the anti-SARS-CoV-2 memory B cell response.
Highlights - Seasonal coronavirus-specific memory B cells contribute an early anti-SARS-Cov2 response - Spike-specific memory B cells with a resting phenotype increase up to 6 months - Somatic mutations accumulate in SARS-CoV2-specific memory B cells over time - Longitudinal study reveals a temporal switch to RBD-specific neutralizing memory B cells Summary.
Correction: Depletion of Regulatory T Cells Induces High Numbers of Dendritic Cells and Unmasks a Subset of Anti-Tumour CD8+CD11c+ PD-1lo Effector T Cells
Fig 5 appears incorrectly in the published article. Please see the correct Fig 5 and its caption here. DCs from PC61-depleted mice and CD4 T cells reduce the percentages of CD8 T cells expressing high level of PD-1. (A) Histograms show cell surface expression of PD-1 on infiltrating CD8 T cells from treated and untreated tumours resected at day 14 (Left) and mean Fluorescence Intensity (MFI) of PD-1 in each group (Right).
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