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Articles by Pascal Sati
Challenges and future directions for multiple sclerosis after the 2024 McDonald diagnostic criteria
The 2024 revision of the McDonald diagnostic criteria is an important step toward earlier and more inclusive diagnosis of multiple sclerosis. Realizing its full potential will require continued refinement of biomarkers, disease stratification and clinical trial approaches.
Flip angle in susceptibility-weighted imaging for the diagnosis of multiple sclerosis – Authors’ reply
We thank Yuki Sonoda and colleagues for sharing their perspective on our 2024 MAGNIMS–CMSC–NAIMS consensus recommendations on the use of MRI for the diagnosis of multiple sclerosis. We appreciate their point regarding the lower visibility of paramagnetic rim lesions (PRL) on susceptibility-weighted images acquired using a low flip angle.
Incorporating the Central Vein Sign Into the Diagnostic Criteria for Multiple Sclerosis
Incorporating the Central Vein Sign Into the Diagnostic Criteria for Multiple Sclerosis The diagnosis of multiple sclerosis (MS), which is codified in the McDonald criteria,1 relies on demonstration of dissemination in space (DIS) and dissemination in time (DIT) following a clinical event typical of an MS exacerbation or documented progression.1 The diagnostic criteria have been iteratively modified to allow an earlier diagnosis, with resulting decrease in specificity.2 This decrease in...
Cognitive impairment, the central vein sign, and paramagnetic rim lesions in RIS
Introduction Radiologically isolated syndrome (RIS) refers to individuals with brain MRI lesions suggestive of multiple sclerosis (MS), but without typical clinical symptoms.
7 Tesla MRI will soon be helpful to guide clinical practice in multiple sclerosis centers – Commentary - Pascal Sati, Daniel S Reich, 2021
Seven-tesla (7T) magnetic resonance imaging (MRI) has become an important tool to investigate noninvasively the cerebral pathology affecting patients with multiple sclerosis (MS).
Detection of central vein should be part of MS diagnostic criteria – Commentary - Jiwon Oh, Pascal Sati,
Thompson, AJ, Banwell, BL, Barkhof, F, . Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria . Lancet Neurol ; 17(2): – . Van der Vuurst de Vries, RM, Mescheriakova, JY, Wong, YYM, . Application of the 2017 revised McDonald criteria for multiple sclerosis to patients with a typical clinically isolated syndrome . JAMA Neurol ; 75(11): – . Solomon, AJ, Weinshenker, BG. Misdiagnosis of multiple sclerosis: Frequency, causes, effects, and prevention . Curr Neurol Neurosci Rep ; 13(12): .
The “central vein sign” in patients with diagnostic “red flags” for multiple sclerosis: A prospective multicenter 3T study
1. Reich, DS, Lucchinetti, CF, Calabresi, PA. Multiple sclerosis. N Engl J Med 2018; 378: 169–180. Google Scholar | Crossref | Medline 2. Thompson, AJ, Banwell, BL, Barkhof, F, et al. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol 2018; 17: 162–173. Google Scholar | Crossref | Medline | ISI 3. Solomon, AJ, Corboy, JR. The tension between early diagnosis and misdiagnosis of multiple sclerosis. Nat Rev Neurol 2017; 13(9): 567–572. Google Scholar | Crossref | Medline 4.
Potential role of iron in repair of inflammatory demyelinating lesions
Research ArticleNeuroscience Free access | 10.1172/JCI126809 Nathanael J. Lee,1,2 Seung-Kwon Ha,1 Pascal Sati,1 Martina Absinta,1 Govind Nair,1 Nicholas J. Luciano,1 Emily C. Leibovitch,3 Cecil C. Yen,4 Tracey A. Rouault,5 Afonso C. Silva,4 Steven Jacobson,3 and Daniel S. Reich1 1Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative
An accepted standard radiological definition of the central vein would be useful to enable uniform imaging practices among clinicians.
Slowly eroding lesions in multiple sclerosis
At autopsy, 20%–40% of chronic multiple sclerosis (MS) lesions are labeled “slowly expanding” and feature myelin phagocytosis at the lesion edge. As pathological lesion classification relies on a single, terminal time point, the rate of lesion expansion cannot be directly measured. To study long-term volume changes in individual MS lesions.
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