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Articles by Patrick Micke
Ageing promotes metastasis via activation of the integrated stress response
Abstract Lung cancer predominantly affects older individuals, yet how physiological ageing influences tumour evolution remains poorly understood1. Here we show that ageing reprograms the evolutionary trajectory of KRAS-driven lung adenocarcinoma, limiting primary tumour growth while promoting metastatic dissemination through epigenetic activation of the integrated stress response (ISR). The ISR effector ATF4 drives epithelial and metabolic plasticity, conferring metastatic competence.
scFFPE-ATAC enables high-throughput single cell chromatin accessibility profiling in formalin-fixed paraffin-embedded samples - Nature Communications
Abstract Formalin-fixed paraffin-embedded (FFPE) samples are the gold standard for tissue preservation in clinical and research settings. Current single-cell chromatin accessibility technologies cannot resolve cell-type-specific epigenetic profiles in FFPE tissues due to extensive DNA damage.
Spatial characterization of proteins in reproductive tissues : Insights into health and disease states
Nyckelord: Spatial analysis; Spatial proteomics; Antibody-based profiling; Immunohistochemistry; Transcriptomics; Cancer-testis antigens; Spermatogenesis; Sperm cells; Testis; Fallopian tube; Ciliated cells; Bioimage analysis; Molekylär medicin; Molecular Medicine; Medicinsk vetenskap; Medical Science; Sammanfattning: The molecular building blocks of human cells have been increasingly mapped in large-scale projects by emerging high-throughput antibody profiling and sequencing methods.
132 Precision diagnostics for immunotherapy: detecting PD1-PDL1 interactions in the in situ microenvironment of cancer tissues
Abstract Background Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. However, their efficacy varies widely among different cancer types and individual patients. Current stratification methods based on PDL1 expression have limited predictive value. Since many ICIs target the PD1-PDL1 pathway, directly detecting PD1-PDL1 interactions within diagnostic samples may offer more precise prediction on immune responses and treatment outcomes.
Highlights • High tumour-infiltrating lymphocytes (TILs) are associated with a higher recurrence risk in human epidermal growth factor receptor 2 -negative ductal carcinoma in situ (DCIS). • TILs can refine the assignment of patients with low-risk DCIS to adjuvant radiotherapy. • TILs do not impact radiotherapy efficacy in DCIS. Abstract Background The immune microenvironment is an important modulator of tumour progression and treatment response.
FGFR1 overexpression in non-small cell lung cancer is mediated by genetic and epigenetic mechanisms and is a determinant of FGFR1 inhibitor response
Highlights • FGFR1, a candidate drug target, is overexpressed in a subset of NSCLC. • NSCLC with high FGFR1 expression defines a distinct molecular and clinical subset. • High FGFR1 protein expression is associated with specific microRNAs and DNA hypomethylation. • A selective FGFR1 antagonist was active in PDX models with FGFR1 amplification and overexpression.
The protein expression profile of ACE2 in human tissues
Abstract The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare and society. For understanding the susceptibility for SARS‐CoV‐2 infection, the cell type‐specific expression of the host cell surface receptor is necessary. The key protein suggested to be involved in host cell entry is angiotensin I converting enzyme 2 (ACE2).
c-MET as a biomarker in patients with surgically resected non-small cell lung cancer
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Fig. 1 Overall Survival curves. 1a: Whole study population, 1b: Patients who received adjuvant treatment, 1c: Patients who did not receive any adjuvant treatment. Highlights •c-MET protein overexpression is not an established biomarker for NSCLC. •IHC was conducted in 725 patients with early stage NSCLC. •IHC staining was quantified using H-scores.
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