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Sama I. Sayin on Muck Rack

Sama I. Sayin

As seen in: Nature, Cell Press, medRxiv
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Articles

Ageing promotes metastasis via activation of the integrated stress response

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By Angana A. H. Patel, Kevin Ali, Ella A Eklund, Samantha Alvarez, Samantha Álvarez, Dorota Raj, Ilayda Altinonder, Maria Schwarz, Kristell Le Gal, Nadia Gul, Jozef P. Bossowski, Ray Pillai, Patrick Micke, Johan Botling, Levent M. Akyürek, Davide Angeletti, Sama I. Sayin, Anetta Härtlova, Thales Papagiannakopoulos, Roger Olofsson Bagge, Anders Ståhlberg, Andreas Hallqvist, Clotilde Wiel, Volkan I. Sayin, Jozefina J. Dzanan, Martin Dankis, Emre Bedel, Emma Jonasson, Heba Albatrok
| Nature Verified
Abstract Lung cancer predominantly affects older individuals, yet how physiological ageing influences tumour evolution remains poorly understood1. Here we show that ageing reprograms the evolutionary trajectory of KRAS-driven lung adenocarcinoma, limiting primary tumour growth while promoting metastatic dissemination through epigenetic activation of the integrated stress response (ISR). The ISR effector ATF4 drives epithelial and metabolic plasticity, conferring metastatic competence.
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Equalizing prognostic disparities in stage III KRAS-mutant NSCLC: addition of durvalumab to combined chemoradiotherapy improves survival

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By Sama I. Sayin, Ella A Eklund, Mathilda Orgard, Delice Wallin
| medRxiv
The authors have declared no competing interest.
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Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

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By Wallenberg Laboratory, Annika Wahlström, Sama I. Sayin, Hanns-Ulrich Marschall
| Cell Press Verified
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