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Volkan I. Sayin on Muck Rack

Volkan I. Sayin

Sweden
As seen in: Nature, Cell Press, Cell Reports
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Articles

STING-dependent peripheral inflammaging drives neurodegeneration via extracellular vesicles

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By Caitlyn Myers, Ivana Maric, Mateo Murillo-Leon, Anneli Strömberg, Daniela Fabrikova, Ivo Fabrik, Meghshree Deshmukh, Josue Enriquez, Kevin Ali, Rossella Crescitelli, Davide Angeletti, Volkan I. Sayin, tao jin, Karim Rafie, Karolina P. Skibicka, Marzena Kurzawa-Akanbi, Gesine Paul, Nelson O. Gekara, Anetta Härtlova, Maria Öberg, Najmeh Saffarzadeh, Laia Rivas-Galvez
| Cell Reports Verified
Keywords: aging inflammation cGAS-STING Parkinson’s disease LRRK2, extracellular vesicles EVs Research topic(s) CP: immunology CP: neuroscience Introduction Aging is a universal and progressive deterioration of cellular and organ functions, an inevitable biological process that occurs in all animals.1,2 However, aging is a heterogeneous process and individual organisms age differently.
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Ageing promotes metastasis via activation of the integrated stress response

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By Angana A. H. Patel, Kevin Ali, Ella A Eklund, Samantha Alvarez, Samantha Álvarez, Dorota Raj, Ilayda Altinonder, Maria Schwarz, Kristell Le Gal, Nadia Gul, Jozef P. Bossowski, Ray Pillai, Patrick Micke, Johan Botling, Levent M. Akyürek, Davide Angeletti, Sama I. Sayin, Anetta Härtlova, Thales Papagiannakopoulos, Roger Olofsson Bagge, Anders Ståhlberg, Andreas Hallqvist, Clotilde Wiel, Volkan I. Sayin, Jozefina J. Dzanan, Martin Dankis, Emre Bedel, Emma Jonasson, Heba Albatrok
| Nature Verified
Abstract Lung cancer predominantly affects older individuals, yet how physiological ageing influences tumour evolution remains poorly understood1. Here we show that ageing reprograms the evolutionary trajectory of KRAS-driven lung adenocarcinoma, limiting primary tumour growth while promoting metastatic dissemination through epigenetic activation of the integrated stress response (ISR). The ISR effector ATF4 drives epithelial and metabolic plasticity, conferring metastatic competence.
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The integrated stress response promotes immune evasion through lipocalin 2 - Nature

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By Jozef P. Bossowski, Ray Pillai, John Kilian, Angela Lau, Mari N Nakamura, Ali Rashidfarrokhi, Yuan Hao, Ruxuan Li, Katherine P. Wu, Takamitsu Hattori, Eliezra Glasser, Akiko Koide, Lidong Wang, André Moreira, Cristina H Hajdu, Sahith Rajalingam, Sarah LeBoeuf Verified, Hortense Le, Seungeun Thera Lee, Cheolyong Joe, Hyemin Kim, Chan-Young Ock, Se-Hoon Lee, Hao Wang, Volkan I. Sayin, Aristotelis Tsirigos, Kwok-Kin Wong, Sergei B Koralov, Mario Pende, Francisco J. Sanchez-Rivera, Diane Simeone, Ioannis K. Zervantonakis, Shohei Koide, Thales Papagiannakopoulos, Angana A. H. Patel
| Nature Verified
Abstract Cancer cells activate the integrated stress response (ISR) to adapt to stress and resist therapy1. ISR signals converge on activating transcription factor 4 (ATF4), which controls cell-intrinsic transcriptional programs that are involved in metabolic adaptation, survival and growth2,3. However, whether the ISR–ATF4 axis influences anti-tumour immune responses remains mostly unknown.
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