Skip To Main Content
Paul Scheet on Muck Rack

Paul Scheet

As seen in: Nature, JAMA Oncology, Texas Medical Center, Lung Cancer, OncoDaily
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile
Back to Paul Scheet’s profile

Articles by Paul Scheet

Germline variants in cancer susceptibility genes among patients with mucosal melanoma

|
By Afsaneh Amouzegar, Xiaogang Wu, James Long, Gabriela Chen, Justin Wong, Curtis Gumbs, Jared C. Malke, Julie Simon, Jianhua Zhang, Priyadharsini Nagarajan, michael davies, Hussein Tawbi, Rodabe N. Amaria, Alexandra Ikeguchi, Shirley Y Su, Ehab Hanna, Roi Weiser, Brian K. Bednarski, Travis Sims, Devarati Mitra, Jennifer Wargo, Jeffrey E. Gershenwald, Paul Scheet, Yao Yu, Kelly Nelson, Jennifer McQuade, P. Andrew Futreal, Sabitha Prabhakaran, Latasha Little, Neus Bota, Isabella C. Glitza Oliva, Chad Huff
| Nature Verified
Abstract Mucosal melanoma (MM) is a rare and aggressive melanoma subtype with poor outcomes and poorly understood risk factors, including the contribution of germline pathogenic variants (PVs). In this study, 346 MM patients treated at MD Anderson Cancer Center underwent germline sequencing of 322 known cancer susceptibility genes, with PV frequencies compared to population controls (gnomAD and TOPMed) using Fisher’s exact test.
Open in Who Shared Issue with article?

Genomic analysis of T Cell receptors reveals lynch syndrome specific immune signatures

|
By Nan Deng, Fahriye Duzagac, Ana Bolivar, Laura Reyes-Uribe, Melissa Taggart, Luigi Ricciardiello, Patrick Lynch, Y. Nancy You, Scott Kopetz, Paul Scheet, Gregory Lizée, Alexandre Reuben, Fátima Marín, Marta Pineda, Krishna Sinha, Ajay Bansal, Gabriel Capellá, Eduardo Vilar, Selvi Thirumurthi
| Nature Verified
Abstract Lynch Syndrome (LS) provides the perfect context to understand DNA mismatch repair deficient carcinogenesis, which is characterized by neoplastic lesions with high rates of shared neoantigens eliciting adaptive immunity through T cell receptor (TCR) recognition. However, the TCR landscape in LS carriers remains unexplored. Here, we perform TCR sequencing of 277 blood samples from LS cancer survivors, previvors, and controls, as well as matching colorectal cancers and pre-cancers.
Open in Who Shared Issue with article?

Genetic determinants and genomic consequences of non-leukemogenic somatic point mutations - Nature Communications

|
By Joshua Weinstock, Sharjeel Chaudhry, Paula Reventun, Cecelia Laurie, Jai Broome, Xiuqing Guo, Patricia A. Peyser, Nathalie Chami, Bruce M. Psaty, Jennifer Brody, Jeong Yun, Michael Cho, Ramachandran S. Vasan, Jennifer Smith, Laura M. Raffield, Jerome I. Rotter, Stephen S. Rich, C. Gu, Chao A. Hsiung, Charles Kooperberg, Rami Nassir, Alex P. Reiner, Vijay Sankaran, Charles J. Lowenstein, Albert Smith, Pradeep Natarajan, Siddhartha Jaiswal, Alexander Bick, Paul Scheet, Paul L. Auer, Alexis Battle, Hyun M. Kang
| Nature Verified
Abstract Clonal hematopoiesis (CH) is defined by the expansion of a lineage of genetically identical cells in blood. Genetic lesions that confer a fitness advantage, such as leukemogenic point mutations or mosaic chromosomal alterations (mCAs), are frequent mediators of CH. However, recent analyses of both single cell-derived colonies of hematopoietic cells and population sequencing cohorts have revealed CH frequently occurs in the absence of known driver genetic lesions.
Open in Who Shared Issue with article?

Lauren Byers and Paul Scheet have been elected fellows of the American Association for the Advancement of Science (AAAS) - OncoDaily

|
By Lauren Averett Byers, Paul Scheet
| OncoDaily
In recognition of their significant achievements to advance cancer care and research, Lauren Byers, M.D., and Paul Scheet, Ph.D., from The University of Texas MD Anderson Cancer Center have been elected fellows of the American Association for the Advancement of Science (AAAS). This distinction stands as one of the highest accolades within the scientific research community. AAAS’s tradition of recognizing leading scientists, who are elected by their peers, dates back to 1874.
Open in Who Shared View Duplicates (4) Issue with article?

Causes of Clonal Hematopoiesis: a Review

|
By Catherine C. Bradley, Steven Lin, Paul Scheet, LiJin Joo
| Texas Medical Center
PURPOSE OF REVIEW: Clonal hematopoiesis (CH) is an age-dependent process detectable using advanced sequencing technologies and is associated with multiple adverse health outcomes including cardiovascular disease and cancer. The purpose of this review is to summarize known causes of CH mutations and to identify key areas and considerations for future research on CH.
Open in Who Shared Issue with article?

Determinants of mosaic chromosomal alteration fitness - Nature Communications

|
By Yash Pershad, Adrienne M. Stilp, Braxton D. Mitchell, Joshua Lewis, Nathalie Chami, Zhe Wang, Kathleen C. Barnes, Nathan Pankratz, Myriam Fornage, Bruce M. Psaty, Joshua C. Bis, Jeong Yun, Andrew Johnson, Rasika A. Mathias, Laura M. Raffield, April P. Carson, Stephen S. Rich, Jerome I. Rotter, Xiuqing Guo, Dan M. Roden, Nora Franceschini, Alex P. Reiner, Paul L. Auer, Paul Scheet, Siddhartha Jaiswal, Joshua Weinstock, Hannah Poisner
| Nature Verified
Abstract Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a hematopoietic stem cell that results in a clonal expansion. These driver mutations can be single nucleotide variants in cancer driver genes or larger structural rearrangements called mosaic chromosomal alterations (mCAs). The factors that influence the variations in mCA fitness and ultimately result in different clonal expansion rates are not well understood.
Open in Who Shared Issue with article?

Author Correction: An atlas of epithelial cell states and plasticity in lung adenocarcinoma - Nature

|
By Guangchun Han, Ansam Sinjab, Warapen Treekitkarnmongkol, Yuejiang Liu, Yunhe Liu, Xuanye Cao, Lorena I. Gomez-Bolanos, Minyue Chen, Edwin R. Parra, Tina Cascone, Seyed Javad Moghaddam, Paul Scheet, Marcelo V. Negrao, John Heymach, Mingyao Li, Steven M. Dubinett, Junya Fujimoto, Luisa M. Solis, Jichao Chen, Linghua Wang
| Nature Verified
Correction to: Nature https://doi.org/10.1038/s41586-024-07113-9 Published online 28 February 2024 In the version of the article initially published, the colours used in the top right panel of Fig. 4a did not match the colour-blind-friendly palette used in that panel’s key. The figure has now been updated in the HTML and PDF versions of the article.
Open in Who Shared View Duplicates (4) Issue with article?

An atlas of epithelial cell states and plasticity in lung adenocarcinoma - Nature

|
By Guangchun Han, Ansam Sinjab, Warapen Treekitkarnmongkol, Yuejiang Liu, Yunhe Liu, Xuanye Cao, Minyue Chen, Edwin R. Parra, Tina Cascone, Seyed Javad Moghaddam, Paul Scheet, Marcelo V. Negrao, John Heymach, Mingyao Li, Steven M. Dubinett, Junya Fujimoto, Luisa M. Solis, Jichao Chen, Linghua Wang, Lorena I. Gomez-Bolanos
| Nature Verified
Abstract Understanding the cellular processes that underlie early lung adenocarcinoma (LUAD) development is needed to devise intervention strategies1. Here we studied 246,102 single epithelial cells from 16 early-stage LUADs and 47 matched normal lung samples. Epithelial cells comprised diverse normal and cancer cell states, and diversity among cancer cells was strongly linked to LUAD-specific oncogenic drivers.
Open in Who Shared Issue with article?

Mosaic chromosomal alterations in blood across ancestries using whole-genome sequencing - Nature Genetics

|
By Yasminka A. Jakubek, Adrienne M. Stilp, Justin Wong, Zuhal Özcan, Kathleen C. Barnes, Joshua C. Bis, April P. Carson, Matthew P. Conomos, Myriam Fornage, Xiuqing Guo, Joshua Lewis, Mitchell J Machiela, Taralynn M. Mack, Rasika A. Mathias, Braxton D. Mitchell, Nathan Pankratz, Patricia A. Peyser, Michael Preuss, Bruce M. Psaty, Laura M. Raffield, Ramachandran S. Vasan, Stephen S. Rich, Jerome I. Rotter, Jennifer Smith, Jeong Yun, Yun Li Verified, Alexander Bick, Paul Scheet
| Nature Verified
Abstract Megabase-scale mosaic chromosomal alterations (mCAs) in blood are prognostic markers for a host of human diseases. Here, to gain a better understanding of mCA rates in genetically diverse populations, we analyzed whole-genome sequencing data from 67,390 individuals from the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine program.
Open in Who Shared Issue with article?

Evaluation of COVID-19 Mortality and Adverse Outcomes in US Patients With or Without Cancer

|
By Mariana Chavez- MacGregor, Paul Scheet, Sharon H. Giordano
| JAMA Oncology Verified
Key Points Question What are the rates of death, mechanical ventilation, intensive care unit stay, and hospitalization among patients with COVID-19 with or without cancer? Findings In this cohort study of 507 307 patients with COVID-19, those with cancer who received anticancer treatment within 3 months before COVID-19 diagnosis had an increased risk of death, intensive care unit admission, and hospitalization.
Open in Who Shared Issue with article?

Haplotype-based profiling of subtle allelic imbalance with SNP arrays

|
By Selina Vattathil, Paul Scheet
| ncbi.nlm.nih.gov
This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml ).
Open in Who Shared Issue with article?
Show More