Paul Scott on Muck Rack

Paul Scott

Bolton
As seen in: Medium, Color Research & Application, Daily Mail, Nature, Wiley Online Library, Taylor & Francis Online, The Conversation, Brookings Institution, The Irish Times, Autoblog and
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Articles

Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity

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By Pantelis Nicola, Andrew Lawson, Yoshihiro Ishida, Luke Wylie, Paul Scott, Kenny Roberts, Luke Harvey, Stefanie V. Lensing, Wei Cheng, Federico Abascal, Daniel Leongamornlert, Yvette Hooks, Matthew Mayho, Nicole Müller-Sienerth, Laura Mincarelli, Flavia Peci, Bee Ling Ng, Georgeina L Jarman, Andrew Russell, Kourosh Saeb-Parsy, Anna L Paterson, Krishna Chatterjee, Raheleh Rahbari, Omer Ali Bayraktar, Michael Stratton, Peter Campbell, John Tadross, Iñigo Martincorena, Alexandra Tidd, Juliette Imbert, Sara Widaa, James Illing, Krishnaa T. A. Mahbubani, Nadia Schoenmakers
| Nature Verified
Abstract Our immune system contains multiple checkpoints to prevent the activation of self-reactive lymphocytes. How some lymphocytes escape these constraints to cause autoimmune disease remains poorly understood. A long-standing hypothesis posits that somatic mutations in immune-regulatory genes may enable self-reactive lymphocytes to bypass tolerance checkpoints1–3, but testing this has been challenging due to technical limitations.
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Concrete Plan

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By Paul Scott
| Brunswick Review Verified
Nineteenth century Heidelberg, then and now a picturesque medieval German city, saw the founding of an enterprise that has flourished for over 150 years. In 1873, Johann Philipp Schifferdecker took over a failed local grain mill and quickly turned it into a manufacturing plant for a new breed of construction material called Portland cement. While cement has been in use continually since ancient times, Portland cement was a new invention, stronger and more reliable than historic versions.
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Security vetting in the commonwealth five eyes states

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By Paul Scott
| Taylor & Francis Online
Vetting is a function which can affect a large number of people in a very significant respect. Vetting accordingly raises in a defined and microcosmic form the two conflicting interests which operate to some extent with regard to the whole functioning of the Service – the interests of the State and the interests of the private individual.Footnote1 Juvenal’s maxim about guarding the guardians has a particular aptness.Footnote2 1.
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