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Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression
1Division of Clinical Immunology & Rheumatology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA 2CAMBAC (Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center), University of Alabama at Birmingham, Birmingham, CA, USA 3Division of Rheumatology, Allergy, and Immunology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, San Diego, CA, USA 4Department of Cellular and Molecular Medicine, University of California,...
Urinary metabolomic biomarker candidates for skeletal muscle wasting in patients with rheumatoid arthritis
Data collection and assessments We reviewed patients' medical records to collect data on age, disease duration (years), current smoking, rheumatoid factor, anti-citrullinated protein antibodies (ACPA), erosions, level of physical activity, disease activity, physical disability, and pharmacological treatment. Dual X-ray absorptiometry (DXA) was used (Lunar Prodigy Primo, GE Medical Systems) to assess body composition. We performed whole-body DXA to estimate appendicular lean mass.
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