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Articles

Connecting clusters of COVID-19: an epidemiological and serological investigation

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By Danielle Anderson, Duke-National, Wycliffe E. Wei, Junxiong Pang
| The Lancet Verified
Summary Background Elucidation of the chain of disease transmission and identification of the source of coronavirus disease 2019 (COVID-19) infections are crucial for effective disease containment. We describe an epidemiological investigation that, with use of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serological assays, established links between three clusters of COVID-19. Methods In Singapore, active case-finding and contact tracing were undertaken for all COVID-19 cases.
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Asthma phenotypes in a multi-ethnic Asian cohort

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By Tunn Ren Tay, Xue Ning Choo, Anthony CA Yii, Duke-National
| Respiratory Medicine Verified
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Fig. 1 Flow diagram showing the repartition of patients from the Changi General Hospital (CGH) and Singapore General Hospital (SGH) databases for study analysis into test and validation cohorts. Fig. 2 Comparisons of input variables between test and validation cohorts across clusters. Boxplots of non-parametric variables (A–C).
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Peripheral serotonin causes dengue virus-induced thrombocytopenia through 5HT2 receptors

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By Duke-National, Chinmay Kumar Mantri
| Blood Verified
Mohamad Fadhli Bin Masri, Chinmay Kumar Mantri, Abhay P. S. Rathore and Ashley L. St. John Blood 2019 133:2325-2337; doi: https://doi.org/10.1182/blood-2018-08-869156 Key Points We identified peripheral serotonin derived from mast cells to be required for dengue virus-induced thrombocytopenia. Therapeutic targeting of platelet 5HT2 receptors reversed platelet activation, aggregation, splenic platelet uptake, and thrombocytopenia.
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